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Antigen-specific T cell responses correlate with decreased occurrence of acute GVHD in a multicenter contemporary cohort.

作者信息

Cruz Conrad Russell Y, Bo Na, Bakoyannis Giorgos, Wright Kaylor E, Chorvinsky Elizabeth A, Powell Allison, Bollard Catherine M, Jacobsohn David, Cooke Kenneth R, Duncan Christine, Krance Robert M, Carpenter Paul A, Rowan Courtney M, Paczesny Sophie

机构信息

Center for Cancer and Immunology Research, Children's National Medical Center, Washington, DC, USA.

GW Cancer Center, George Washington University, Washington, DC, USA.

出版信息

Bone Marrow Transplant. 2022 Feb;57(2):279-281. doi: 10.1038/s41409-021-01456-x. Epub 2021 Oct 28.

DOI:10.1038/s41409-021-01456-x
PMID:34711916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8821012/
Abstract
摘要

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Antigen-specific T cell responses correlate with decreased occurrence of acute GVHD in a multicenter contemporary cohort.在一个多中心当代队列中,抗原特异性T细胞反应与急性移植物抗宿主病发生率降低相关。
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Kinetic of regulatory CD25high and activated CD134+ (OX40) T lymphocytes during acute and chronic graft-versus-host disease after allogeneic bone marrow transplantation.异基因骨髓移植后急性和慢性移植物抗宿主病期间调节性CD25高表达和活化的CD134 +(OX40)T淋巴细胞的动力学。
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引用本文的文献

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Inflammatory CD4/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology.炎性 CD4/CD8 双阳性人类 T 细胞源自反应性 CD8 T 细胞,足以介导移植物抗宿主病病理学。
Sci Adv. 2023 Mar 24;9(12):eadf0567. doi: 10.1126/sciadv.adf0567.

本文引用的文献

1
CD28 fusions: an opportunity for young ATL?CD28融合:年轻成人T细胞白血病/淋巴瘤的一个契机?
Blood. 2020 Apr 23;135(17):1415-1416. doi: 10.1182/blood.2020004958.
2
Biomarkers for Early Complications After Hematopoietic Stem Cell Transplantation.造血干细胞移植后早期并发症的生物标志物
Clin Lab Med. 2019 Mar;39(1):61-72. doi: 10.1016/j.cll.2018.10.005. Epub 2018 Dec 18.
3
Biomarkers for posttransplantation outcomes.移植后结局的生物标志物。
Blood. 2018 May 17;131(20):2193-2204. doi: 10.1182/blood-2018-02-791509. Epub 2018 Apr 5.
4
Plasma biomarkers of acute GVHD and nonrelapse mortality: predictive value of measurements before GVHD onset and treatment.急性移植物抗宿主病和非复发死亡率的血浆生物标志物:移植物抗宿主病发作和治疗前测量的预测价值
Blood. 2015 Jul 2;126(1):113-20. doi: 10.1182/blood-2015-03-636753. Epub 2015 May 18.
5
Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease.胰岛衍生 3α 是胃肠道移植物抗宿主病的生物标志物。
Blood. 2011 Dec 15;118(25):6702-8. doi: 10.1182/blood-2011-08-375006. Epub 2011 Oct 6.
6
PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells.PD-L1 阻断有效地恢复了强烈的移植物抗白血病效应,而在延迟过继转移 T 细胞受体基因工程同种异体 CD8+ T 细胞后没有移植物抗宿主病。
Blood. 2011 Jan 20;117(3):1030-41. doi: 10.1182/blood-2010-04-283119. Epub 2010 Nov 9.