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巴西卡拉雅斯国家森林中昆斯精油的化学成分与抗菌活性

Chemical Composition and Antibacterial Activity of the Kunth Essential Oil from the Carajás National Forest, Brazil.

作者信息

Ribeiro Fabiana Paiva, Santana de Oliveira Mozaniel, de Oliveira Feitosa André, Santana Barbosa Marinho Patricia, Moacir do Rosario Marinho Andrey, de Aguiar Andrade Eloisa Helena, Favacho Ribeiro Alcy

机构信息

Faculty of Chemistry, Federal University of Pará, Ananindeua Campus, Tv. We Vinte e Seis, 2, Coqueiro, Ananindeua, Portugal 67130-660, Brazil.

Adolpho Ducke Laboratory, Botany Coordination, Emílio Goeldi Museum, Av. Perimetral, 1901, Terra Firme, Belém, Portugal 66077-830, Brazil.

出版信息

Evid Based Complement Alternat Med. 2021 Oct 19;2021:9930336. doi: 10.1155/2021/9930336. eCollection 2021.

Abstract

Species of the genus are rich in essential oils and have shown antibacterial properties, which may be related to oils' chemical composition. The present work aimed to evaluate the antimicrobial potential of Kunth against two bacteria strains: and . Leaf essential oils were obtained by hydrodistillation in a modified Clevenger-type apparatus, and their chemical composition was determined by gas chromatography coupled to mass spectrometry (GC/MS) and flame ionization detection (GC/FID). We identified 28 compounds, representing 98.87% of the total concentration of the essential oil. The compounds identified at the highest concentrations were 1,8-cineole (35.04%), carvacrol (11.32%), p-cymene (8.53%), -pinene (7.17%), and -terpinene (7.16%). The leaf essential oil of showed antibacterial action on biological isolates of and . For , the oil presented bactericidal action at concentrations of 5-20 L/mL. Regarding , the bactericidal effect was noted at 20 L/mL and the bacteriostatic action was noted around 2.5-10 L/mL. Given the results obtained, essential oil showed promising biological potential against Gram-positive () and Gram-negative () bacteria, thus encouraging further studies on substances isolated from this species to contribute to the development of new antimicrobial drugs.

摘要

该属植物富含精油,并已显示出抗菌特性,这可能与精油的化学成分有关。本研究旨在评估Kunth对两种细菌菌株([具体细菌名称1]和[具体细菌名称2])的抗菌潜力。通过在改良的克莱文杰型装置中进行水蒸馏获得叶精油,并通过气相色谱-质谱联用(GC/MS)和火焰离子化检测(GC/FID)确定其化学成分。我们鉴定出28种化合物,占精油总浓度的98.87%。浓度最高的化合物为1,8-桉叶素(35.04%)、香芹酚(11.32%)、对伞花烃(8.53%)、α)、α-蒎烯(7.17%)和γ-松油烯(7.16%)。[植物名称]的叶精油对[具体细菌名称1]和[具体细菌名称2]的生物分离株具有抗菌作用。对于[具体细菌名称1],该精油在浓度为5 - 20μL/mL时表现出杀菌作用。对于[具体细菌名称2],在20μL/mL时观察到杀菌效果,在2.5 - 10μL/mL左右观察到抑菌作用。鉴于所获得的结果,[植物名称]精油对革兰氏阳性([具体细菌名称1])和革兰氏阴性([具体细菌名称2])细菌显示出有前景的生物潜力,因此鼓励对从该物种中分离出的物质进行进一步研究,以促进新型抗菌药物的开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7160/8548111/01712c825c8d/ECAM2021-9930336.001.jpg

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