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RON 介导子宫内膜腺癌的肿瘤促进作用。

RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma.

机构信息

Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006 Zhejiang, China.

Ningbo Institution of Medical Science, Ningbo, 315000 Zhejiang, China.

出版信息

Biomed Res Int. 2021 Oct 19;2021:2282916. doi: 10.1155/2021/2282916. eCollection 2021.

DOI:10.1155/2021/2282916
PMID:34712728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8548096/
Abstract

Endometrial adenocarcinoma is one of the most prevalent female reproductive tract cancers in the world, and the development of effective treatment is still the main goal of its current research. Epithelial-mesenchymal transition (EMT) plays a significant part in the occurrence and development of epithelial carcinoma, including endometrial adenocarcinoma. Recepteur d'origine nantais (RON) induces EMT and promotes proliferation, migration, and invasion in various epithelial-derived cancers, but its role in endometrial adenocarcinoma is still poorly studied. The purpose of this study is to verify the overexpression of RON in endometrial adenocarcinoma and to explore its specific roles. RON expression in tumor lesions was verified by immunohistochemical staining, HEC-1B cells were used to construct stable cell lines with RON overexpression or knockdown to investigate the effects of RON on the function of endometrial adenocarcinoma cells, and xenotransplantation experiment was carried out in nude mice to explore the effect of RON on the growth of endometrial adenocarcinoma . This study revealed that RON could promote the proliferation, migration, and invasion of HEC-1B cells and induce EMT, and these effects were regulated through the Smad pathway. RON overexpression could promote growth of endometrial adenocarcinoma cells in nude mice, while its inhibitor BMS777607 could restrict this role. RON played an important role in endometrial adenocarcinoma and had a potential to become a new therapeutic target for endometrial adenocarcinoma.

摘要

子宫内膜腺癌是世界上最常见的女性生殖道癌症之一，开发有效的治疗方法仍然是其当前研究的主要目标。上皮-间充质转化（EMT）在包括子宫内膜腺癌在内的上皮性癌的发生和发展中起着重要作用。纳坦受体（RON）在各种上皮来源的癌症中诱导 EMT 并促进增殖、迁移和侵袭，但它在子宫内膜腺癌中的作用仍研究甚少。本研究旨在验证 RON 在子宫内膜腺癌中的过表达，并探讨其具体作用。通过免疫组织化学染色验证 RON 在肿瘤病变中的表达，使用 HEC-1B 细胞构建 RON 过表达或敲低的稳定细胞系，以研究 RON 对子宫内膜腺癌细胞功能的影响，并在裸鼠中进行异种移植实验，以探讨 RON 对子宫内膜腺癌生长的影响。本研究表明，RON 可促进 HEC-1B 细胞的增殖、迁移和侵袭，并诱导 EMT，这些作用通过 Smad 通路调节。RON 过表达可促进裸鼠子宫内膜腺癌细胞的生长，而其抑制剂 BMS777607 可限制这一作用。RON 在子宫内膜腺癌中起重要作用，有潜力成为子宫内膜腺癌的新治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/39a3f4a9fe02/BMRI2021-2282916.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/e09cd9402840/BMRI2021-2282916.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/80c448a643dd/BMRI2021-2282916.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/4e8be9ae6558/BMRI2021-2282916.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/47ba587288bb/BMRI2021-2282916.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/39a3f4a9fe02/BMRI2021-2282916.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/e09cd9402840/BMRI2021-2282916.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/80c448a643dd/BMRI2021-2282916.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/4e8be9ae6558/BMRI2021-2282916.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/47ba587288bb/BMRI2021-2282916.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfe2/8548096/39a3f4a9fe02/BMRI2021-2282916.005.jpg

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2
Recepteur d'origine nantais contributes to the development of endometriosis via promoting epithelial-mesenchymal transition of a endometrial epithelial cells.法国南特起源受体通过促进子宫内膜上皮细胞的上皮-间充质转化促进子宫内膜异位症的发展。
J Cell Mol Med. 2021 Feb;25(3):1601-1612. doi: 10.1111/jcmm.16261. Epub 2021 Jan 6.
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