Dhanani Rahim, Faisal Muhammad, Akram Mahir, Shakeel Osama, Zahid Muhammad Toqeer, Hassan Aamna, Hussain Raza
Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Pakistan.
Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Pakistan.
Turk Arch Otorhinolaryngol. 2021 Sep;59(3):188-192. doi: 10.4274/tao.2021.2021-2-5. Epub 2021 Oct 15.
The objective of this study was to identify the characteristic features of patients with distant metastasis as the only manifestation of well-differentiated thyroid cancers and to analyze the treatment outcomes.
A retrospective review of all patients with well-differentiated thyroid cancers and distant metastasis as the sole initial presentation was carried out. Data regarding age, gender, tumor histology, site, symptoms, and treatment outcomes were collected.
There were 10 patients who presented with distant metastasis as the only presentation. The mean age was 56.1 years. Eight (80%) patients had osseous metastasis, one (10%) had pulmonary and one (10%) had both. Follicular thyroid carcinoma was more common and seen in six (60%) patients. Seven (77.8%) out of nine patients had demised within five years of initial presentation.
Distant metastases without a neck lump as the initial presentation of well-differentiated thyroid cancers are extremely rare. No specific guidelines are available to manage such patients due to lack of relevant data in the literature.
本研究的目的是确定以远处转移为唯一表现的高分化甲状腺癌患者的特征，并分析治疗结果。
对所有以远处转移为唯一初始表现的高分化甲状腺癌患者进行回顾性研究。收集有关年龄、性别、肿瘤组织学、部位、症状和治疗结果的数据。
有10例患者以远处转移为唯一表现。平均年龄为56.1岁。8例（80%）患者发生骨转移，1例（10%）发生肺转移，1例（10%）同时发生骨转移和肺转移。滤泡状甲状腺癌更为常见，6例（60%）患者为此类型。9例患者中有7例（77.8%）在初次就诊后5年内死亡。
高分化甲状腺癌以远处转移而非颈部肿块为初始表现极为罕见。由于文献中缺乏相关数据，尚无针对此类患者的具体管理指南。
