Reynoso E E, Keating A, Baker M A
Cancer. 1987 Jun 1;59(11):1963-5. doi: 10.1002/1097-0142(19870601)59:11<1963::aid-cncr2820591121>3.0.co;2-c.
A 22-year-old woman presented with acute lymphoblastic leukemia (ALL) during pregnancy. She had been successfully treated for ALL at the age of 3 years and had received maintenance treatment for 11 years. Complete remission of 3 years or more is an important factor for long-term survival and potential cure. Relapses may occur in the first 5 years after maintenance is discontinued. Later relapses are distinctly unusual. We have found six more cases of ALL occurring long after the initial remission in the English literature. It is unclear whether late relapse represents true relapse or a second leukemia. Life-long follow-up of children with ALL may be necessary.
一名22岁女性在孕期被诊断为急性淋巴细胞白血病（ALL）。她3岁时曾成功接受ALL治疗，并接受了11年的维持治疗。3年或更长时间的完全缓解是长期生存和潜在治愈的重要因素。维持治疗中断后的前5年可能会复发。后期复发极为罕见。我们在英文文献中又发现了6例ALL在首次缓解后很长时间才发生的病例。尚不清楚晚期复发是真正的复发还是第二种白血病。可能需要对ALL患儿进行终身随访。
