Uderzo C, Rajnoldi A C, Schirò R, di Lelio A, Jankovic M, Conter V, Locasciulli A, Masera G
Clinica Pediatrica, Università di Milano, Ospedale S. Gerardo, Monza, Italy.
Cancer. 1988 Oct 1;62(7):1359-63. doi: 10.1002/1097-0142(19881001)62:7<1359::aid-cncr2820620720>3.0.co;2-i.
Neuroblastoma was diagnosed in a child after a 20-month remission of a pre-B acute lymphoblastic leukemia (ALL). Clumps of atypical cells suggestive of neuroblastoma were seen in the bone marrow. They were positive for monoclonal antibody (MoAb) UJ13A (neuroblastoma cells) and negative for MoAb T29/33 (anti-leucocyte common antigen CD45) with immunocytochemical staining. A right paravertebral mass displacing the kidney was demonstrated by abdominal echotomography, and serum vanilmandelic acid was slightly increased. Despite specific chemotherapy against neuroblastoma and after a transient clinical improvement, the patient died 7 months later of disseminated disease. Immunocytochemical staining on cells frozen at diagnosis of leukemia with MoAb UJ13A and T29/33 was unable to demonstrate neuroblastoma cells and showed the pattern usually observed in leukemia (UJ13A- and T29/33+).
一名儿童在B系急性淋巴细胞白血病（ALL）缓解20个月后被诊断出神经母细胞瘤。骨髓中可见提示神经母细胞瘤的非典型细胞团。免疫细胞化学染色显示，它们对单克隆抗体（MoAb）UJ13A（神经母细胞瘤细胞）呈阳性，而对MoAb T29/33（抗白细胞共同抗原CD45）呈阴性。腹部超声断层扫描显示右侧椎旁有一肿块，使肾脏移位，血清香草扁桃酸略有升高。尽管针对神经母细胞瘤进行了特异性化疗，且临床有短暂改善，但患者7个月后死于播散性疾病。用MoAb UJ13A和T29/33对白血病诊断时冷冻的细胞进行免疫细胞化学染色，未能显示神经母细胞瘤细胞，显示出白血病中通常观察到的模式（UJ13A阴性和T29/33阳性）。
