Roldán-Jiménez Cristina, Martín-Martín Jaime, Pajares Bella, Ribelles Nuria, Alba Emilio, Cuesta-Vargas Antonio I
Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad de Málaga, Andalucía Tech., Málaga, Spain.
Instituto de Investigación Biomédica de Málaga (IBIMA), Grupo de Clinimetría (F-14), Málaga, Spain.
PM R. 2023 Feb;15(2):151-156. doi: 10.1002/pmrj.12731. Epub 2021 Nov 23.
Breast cancer survivors may have side effects from treatment, such as impaired upper limb function after surgery, which may be affected by a range of factors.
To analyze the association between upper limb function and strength, fear avoidance, and central sensitization symptoms among breast cancer survivors, and to explore how these variables are associated with upper limb function.
Validation cohort.
Institutional practice at a public hospital.
One hundred seventy-four breast cancer survivors who had been undergone surgery for a primary tumor.
Not applicable.
Upper limb function was measured by the Upper Limb Functional Index (ULFI-Sp). Independent outcomes were: handgrip strength, which was measured using a Jamar dynamometer on the dominant side; fear avoidance, measured using the Fear-Avoidance Components Scale (FACS-Sp); and central sensitization symptoms, which were measured using the Central Sensitisation Inventory (CSI-Sp). A linear regression model explaining the ULFI-Sp results was constructed with the variables.
The regression model was significant (F = 46.826; p < .0001), and explained 45% of the variance of the ULFI values. All variables showed strong associations with upper limb function.
Greater upper limb function is associated with higher grip strength, lower fear-avoidance behavior and fewer central sensitization symptoms among breast cancer survivors. These variables explained 45% of the upper limb function in the regression model, and concur with earlier research showing that factors such as central sensitization symptoms and kinesiophobia negatively affect upper limb function in such patients. Clinicians should therefore take into account strength, fear avoidance, and central sensitization symptoms when considering interventions aimed at improving upper limb function among breast cancer survivors.
乳腺癌幸存者可能会有治疗带来的副作用，比如手术后上肢功能受损，这可能受到一系列因素的影响。
分析乳腺癌幸存者上肢功能与力量、恐惧回避及中枢敏化症状之间的关联，并探讨这些变量与上肢功能是如何关联的。
验证队列研究。
一家公立医院的机构实践。
174名因原发性肿瘤接受手术的乳腺癌幸存者。
不适用。
上肢功能通过上肢功能指数（ULFI-Sp）进行测量。独立的观察结果包括：握力，使用Jamar测力计在优势侧进行测量；恐惧回避，使用恐惧回避成分量表（FACS-Sp）进行测量；以及中枢敏化症状，使用中枢敏化量表（CSI-Sp）进行测量。用这些变量构建一个解释ULFI-Sp结果的线性回归模型。
回归模型具有显著性（F = 46.826；p <.0001），并解释了ULFI值45%的方差。所有变量均与上肢功能显示出强关联。
在乳腺癌幸存者中，上肢功能越好与握力越高、恐惧回避行为越少以及中枢敏化症状越少相关。这些变量在回归模型中解释了45%的上肢功能情况，这与早期研究结果一致，即中枢敏化症状和运动恐惧等因素会对这类患者的上肢功能产生负面影响。因此，临床医生在考虑旨在改善乳腺癌幸存者上肢功能的干预措施时，应考虑力量、恐惧回避和中枢敏化症状等因素。
