Liu Sicong, Zhang Hanbing, Li Xiao, Liu Ning, Qiao Aike
Department of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, P.R.China.
Intelligent Physiological Measurement and Clinical Translation, Beijing International Base for Scientific and Technological Cooperation, Beijing 100124, P.R.China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021 Oct 25;38(5):858-868. doi: 10.7507/1001-5515.202012011.
To solve the problem of stent malapposition of intravascular stents, explore the design method of intravascular body-fitted stent structure and to establish an objective apposition evaluation method, the support and apposition performance of body-fitted stent in the stenotic vessels with different degrees of calcified plaque were simulated and analyzed. The traditional tube-mesh-like stent model was constructed by using computational aided design tool SolidWorks, and based on this model, the body-fitted stent model was designed by means of projection algorithm. Abaqus was used to simulate the crimping-expansion-recoil process of the two stents in the stenotic vessel with incompletely calcified plaque and completely calcified plaque respectively. A comprehensive method for apposition evaluation was proposed considering three aspects such as separation distance, fraction of non-contact area and residual volume. Compared with the traditional stent, the separation distances of the body-fitted stent in the incompletely calcified plaque model and the completely calcified plaque model were decreased by 21.5% and 22.0% respectively, the fractions of non-contact areas were decreased by 11.3% and 11.1% respectively, and the residual volumes were decreased by 93.1% and 92.5% respectively. The body-fitted stent improved the apposition performance and was effective in both incompletely and completely calcified plaque models. The established apposition performance evaluation method of stent considered more geometric factors, and the results were more comprehensive and objective.
为解决血管内支架贴壁不良问题，探索血管内贴合人体的支架结构设计方法并建立客观的贴壁评估方法，对不同程度钙化斑块狭窄血管中贴合人体的支架的支撑和贴壁性能进行了模拟分析。利用计算机辅助设计工具SolidWorks构建传统的管状网格状支架模型，并在此模型基础上通过投影算法设计贴合人体的支架模型。分别使用Abaqus模拟两种支架在不完全钙化斑块和完全钙化斑块狭窄血管中的压握-扩张-回弹过程。从分离距离、非接触面积分数和残余体积三个方面提出了一种综合的贴壁评估方法。与传统支架相比，贴合人体的支架在不完全钙化斑块模型和完全钙化斑块模型中的分离距离分别降低了21.5%和22.0%，非接触面积分数分别降低了11.3%和11.1%，残余体积分别降低了93.1%和92.5%。贴合人体的支架改善了贴壁性能，在不完全钙化斑块模型和完全钙化斑块模型中均有效。所建立的支架贴壁性能评估方法考虑了更多几何因素，结果更全面、客观。
