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[非均匀泊松比抗移位气管支架结构设计与力学分析的数值研究]

[Numerical study on structural design and mechanical analysis of anti-migration tracheal stent with non-uniform Poisson's ratio].

作者信息

Tao Keyi, Sun Hao, Liu Zhao, Du Tianming, Zhang Yanping, Cheng Yuan, Huang Junfang, Qiao Aike

机构信息

Department of Biomedical Engineering, College of Chemistry and Life Sciences, Beijing University of Technology, Beijing 100124, P. R. China.

Intelligent Physiological Measurement and Clinical Translation, Beijing International Base for Scientific and Technological Cooperation, Beijing 100124, P. R. China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2024 Oct 25;41(5):1035-1045. doi: 10.7507/1001-5515.202402014.

Abstract

Stent migration is one of the common complications after tracheal stent implantation. The causes of stent migration include size mismatch between the stent and the trachea, physiological movement of the trachea, and so on. In order to solve the above problems, this study designed a non-uniform Poisson ratio tracheal stent by combining the size and structure of the trachea and the physiological movement of the trachea to improve the migration of the stent, meanwhile ensuring the support of the stent. In this study, the stent corresponding to cartilage was constructed with negative Poisson's ratio, and the stent corresponding to the circular connective tissue and muscular membrane was constructed with positive Poisson's ratio. And four kinds of non-uniform Poisson's ratio tracheal stents with different link lengths and negative Poisson's ratio were designed. Then, this paper numerically simulated the expansion and rebound process of the stent after implantation to observe the support of the stent, and further simulated the stretch movement of the trachea to calculate the diameter changes of the stent corresponding to different negative Poisson's ratio structures. The axial migration of the stent was recorded by applying different respiratory pressure to the wall of the tracheal wall to evaluate whether the stent has anti-migration effect. The research results show that the non-uniform Poisson ratio stent with connecting rod length of 3 mm has the largest diameter expansion in the negative Poisson ratio section when the trachea was stretched. Compared with the positive Poisson's ratio structure, the axial migration during vigorous breathing was reduced from 0.024 mm to 0.012 mm. The negative Poisson's ratio structure of the non-uniform Poisson's ratio stent designed in this study did not fail in the tracheal expansion effect. Compared with the traditional stent, the non-uniform Poisson's ratio tracheal stent has an anti-migration effect under the normal movement of the trachea while ensuring the support force of the stent.

摘要

支架移位是气管支架植入术后常见的并发症之一。支架移位的原因包括支架与气管尺寸不匹配、气管的生理运动等。为了解决上述问题,本研究结合气管的尺寸结构及气管的生理运动,设计了一种非均匀泊松比气管支架,以改善支架移位情况,同时保证支架的支撑性。本研究中,对应软骨的支架采用负泊松比构建,对应环形结缔组织和肌膜的支架采用正泊松比构建。并设计了四种不同连杆长度且带有负泊松比的非均匀泊松比气管支架。然后,本文对支架植入后的扩张及回弹过程进行数值模拟,观察支架的支撑情况,进一步模拟气管的拉伸运动,计算不同负泊松比结构对应的支架直径变化。通过对气管壁施加不同呼吸压力记录支架的轴向移位情况,评估支架是否具有抗移位效果。研究结果表明,当气管拉伸时,连杆长度为3mm的非均匀泊松比支架在负泊松比部分的直径扩张最大。与正泊松比结构相比,剧烈呼吸时的轴向移位从0.024mm降至0.012mm。本研究设计的非均匀泊松比支架的负泊松比结构在气管扩张效果上未失效。与传统支架相比,非均匀泊松比气管支架在气管正常运动情况下具有抗移位效果,同时保证了支架的支撑力。

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本文引用的文献

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Trachea Mechanics for Tissue Engineering Design.用于组织工程设计的气管力学
ACS Biomater Sci Eng. 2018 Apr 9;4(4):1272-1284. doi: 10.1021/acsbiomaterials.7b00738. Epub 2018 Mar 12.
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A Tubular Biomaterial Construct Exhibiting a Negative Poisson's Ratio.一种呈现负泊松比的管状生物材料构建体。
PLoS One. 2016 May 27;11(5):e0155681. doi: 10.1371/journal.pone.0155681. eCollection 2016.

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