Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan430022, China.
Br J Nutr. 2022 Sep 28;128(6):1100-1107. doi: 10.1017/S0007114521004335. Epub 2021 Oct 29.
To determine the association between hearing loss and environmental Pb, Cd and Se exposure, a total of 1503 American adults from National Health and Nutrition Examination Survey (NHANES) (2011-2012) were assessed. The average of four audiometric frequencies (0·5, 1, 2 and 4 kHz) was used to identify speech-frequency hearing loss (SFHL), while the average of 3 audiometric frequencies (3, 4 and 6 kHz) was used to identify high-frequency hearing loss (HFHL). HFHL adjusted OR determined by comparing the highest and lowest blood Pb and Cd quartiles were 1·98 (95 % CI: 1·27, 3·10) and 1·81 (95 % CI: 1·13, 2·90), respectively. SFHL was significantly associated with blood Cd with the OR = 2·42 for the highest quartile. When further stratified by age, this association appeared to be limited to adults aged 35-52 years. After stratified by gender, except for Pb and Cd, we observed that blood Se showed a dose-dependent association with SFHL in men. In women, only Cd showed a dose-dependent association with speech and high-frequency hearing loss. Hearing loss was positively associated with blood levels of Pb and Cd. Additionally, our study provided novel evidence suggesting that excessive Se supplement would increase SFHL risk in men.
为了确定听力损失与环境铅、镉和硒暴露之间的关系，我们评估了来自国家健康和营养检查调查（NHANES）（2011-2012 年）的 1503 名美国成年人。使用四个听力频率（0.5、1、2 和 4 kHz）的平均值来识别言语频率听力损失（SFHL），而使用三个听力频率（3、4 和 6 kHz）的平均值来识别高频听力损失（HFHL）。通过比较血液铅和镉四分位数的最高和最低值来确定 HFHL 调整后的比值比（OR），结果分别为 1.98（95 % CI：1.27，3.10）和 1.81（95 % CI：1.13，2.90）。HFHL 与血液镉显著相关，最高四分位数的 OR = 2.42。当按年龄进一步分层时，这种关联似乎仅限于 35-52 岁的成年人。按性别分层后，除了铅和镉，我们观察到血液硒与男性的 SFHL 呈剂量依赖性关联。在女性中，只有镉与言语和高频听力损失呈剂量依赖性关联。听力损失与血液铅和镉水平呈正相关。此外，我们的研究提供了新的证据表明，过量的硒补充会增加男性 SFHL 的风险。
