Department of Pathology, the First Affiliated Hospital of China Medical University,Shenyang, China.
Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Medicine (Baltimore). 2021 Oct 29;100(43):e27570. doi: 10.1097/MD.0000000000027570.
Astroblastoma is a rare tumor of the central nervous system with uncertain biological behavior and origin. Its histopathological features have been well established, while, to our knowledge, astroblastoma with oligodendroglial-like cells have not been reported.
A 15-year-old girl presented with nausea, vomiting, headache, and visual disturbance.
Magnetic resonance imaging revealed a large neoplasm in the left temporal. Histologically, the tumor showed solid and pseudopapillary structure. Immunohistochemical staining showed that the tumor cells were positive for glial fibrillary acidic protein and vimentin. The oligodendroglial-like cells were positive for glial fibrillary acidic protein, vimentin, and oligodendrocyte transcription factor 2. The antigen KI67 labeling index was about 4%. Sequencing for isocitrate dehydrogenase (IDH) 1 codon 132 and IDH2 codon 172 gene mutations showed negative results. Furthermore, fluorescent analysis revealed neither 1p nor 19q deletion in the lesion. Based on these findings, the girl was finally diagnosed as astroblastoma.
A craniotomy with total excision of the tumor was performed.
The follow-up time was 1 year, no evidence of disease recurrence was found in magnetic resonance imaging.
Cerebral astroblastoma with oligodendroglial-like cells is a clinically rare tumor of central nervous system. Clear distinction and diagnosis are critical.
神经胶质母细胞瘤是一种罕见的中枢神经系统肿瘤，其生物学行为和起源尚不确定。其组织病理学特征已经得到很好的确立，然而据我们所知，具有少突胶质样细胞的神经胶质母细胞瘤尚未见报道。
一名 15 岁女孩因恶心、呕吐、头痛和视力障碍就诊。
磁共振成像显示左颞叶有一个大肿瘤。组织学上，肿瘤呈实性和假乳头状结构。免疫组织化学染色显示肿瘤细胞胶质纤维酸性蛋白和波形蛋白阳性。少突胶质样细胞胶质纤维酸性蛋白、波形蛋白和少突胶质细胞转录因子 2 阳性。抗原 KI67 标记指数约为 4%。对异柠檬酸脱氢酶（IDH）1 密码子 132 和 IDH2 密码子 172 基因突变进行测序，结果均为阴性。此外，荧光分析显示病变中既没有 1p 缺失也没有 19q 缺失。基于这些发现，该女孩最终被诊断为神经胶质母细胞瘤。
行开颅肿瘤全切除术。
随访时间为 1 年，磁共振成像未见疾病复发迹象。
大脑神经胶质母细胞瘤伴少突胶质样细胞是一种中枢神经系统罕见肿瘤。明确的鉴别和诊断至关重要。
