Department of Oncology, the Affiliated Zhuzhou Hospital Xiangya Medical College CSU, Zhuzhou, Hunan, China.
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
Medicine (Baltimore). 2021 Oct 29;100(43):e27693. doi: 10.1097/MD.0000000000027693.
The prognosis of patients with postmenopausal breast cancer (PBC) could be improved by the early detection of intraocular metastases (IOMs). However, serum biomarkers for IOMs in PBC remain elusive. In the current study, we investigated patients with PBC, and compared serum parameters in an IOM and a non-IOM group, and then differentiated the risk factors related to IOMs. A comparison between an IOM and a non-IOM (NIOM) group was performed using Student t-test and a Chi-Squared test. After constructing a Poisson regression model to identify risk factors, we plotted receiver operating characteristic curves to evaluate the predictive value of significant risk factors in detecting IOMs. The incidence of IOMs in PBC was 1.16%. The histopathology results were not significantly different between the 2 groups. The levels of serum carbohydrate antigen 125 (CA-125), carbohydrate antigen 15-3 (CA15-3) and alkaline phosphatase were significantly elevated in IOMs compared with NIOMs (P = .082, P < .001, and P < .001, respectively). Compared with NIOMs, age, carbohydrate antigen 19 to 9, hemoglobin, calcium, total cholesterol, low-density lipoprotein (LDL) and apolipoprotein A1 were remarkably lower in IOMs (P = .038, P < .001, P < .001, P = .032, P = .041, P < .001, and P = .001, respectively). Poisson regression suggested that CA-125, CA15-3 and LDL were contributing to IOMs in PBC as risk factors (OR = 1.003, 95% CI: 1.001-1.005; OR = 1.025, 95% CI: 1.019-1.033; OR = 0.238, 95% CI: 0.112-0.505, respectively). A receiver operating characteristic curve revealed that the cut-off values for CA-125, CA15-3 and LDL were 16.78 0 U/mL, 63.175 U/mL, and 2.415 mmol/L, respectively. The combination of CA-125 and CA15-3 showed significant diagnostic value (area under the curve [AUC] = 0.982, P < .001). Our investigation suggests that CA-125, CA15-3 and LDL remarkably predict IOMs in PBC as risk factors, and the combination of CA-125 and CA15-3 shows considerable diagnostic value.
患有绝经后乳腺癌（PBC）的患者通过早期发现眼内转移（IOM）可以改善预后。然而，PBC 患者的 IOM 血清生物标志物仍然难以捉摸。在本研究中，我们研究了患有 PBC 的患者，并比较了 IOM 组和非 IOM 组的血清参数，然后区分了与 IOM 相关的危险因素。使用学生 t 检验和卡方检验对 IOM 组和非 IOM（NIOM）组进行比较。在构建识别危险因素的泊松回归模型后，我们绘制了受试者工作特征曲线，以评估显著危险因素在检测 IOM 中的预测价值。PBC 患者 IOM 的发生率为 1.16%。两组的组织病理学结果无显着差异。与 NIOM 相比，IOM 中血清糖抗原 125（CA-125）、糖抗原 15-3（CA15-3）和碱性磷酸酶的水平显着升高（P=0.082，P<0.001 和 P<0.001，分别）。与 NIOM 相比，IOM 中的年龄、肿瘤标志物 19-9、血红蛋白、钙、总胆固醇、低密度脂蛋白（LDL）和载脂蛋白 A1 显着降低（P=0.038，P<0.001，P<0.001，P=0.032，P=0.041，P<0.001 和 P=0.001，分别）。泊松回归表明，CA-125、CA15-3 和 LDL 是 PBC 中 IOM 的危险因素（OR=1.003，95%CI：1.001-1.005；OR=1.025，95%CI：1.019-1.033；OR=0.238，95%CI：0.112-0.505，分别）。受试者工作特征曲线显示，CA-125、CA15-3 和 LDL 的截断值分别为 16.780 U/mL、63.175 U/mL 和 2.415 mmol/L。CA-125 和 CA15-3 的组合具有显著的诊断价值（曲线下面积[AUC]=0.982，P<0.001）。我们的研究表明，CA-125、CA15-3 和 LDL 显着预测 PBC 中的 IOM 作为危险因素，CA-125 和 CA15-3 的组合具有相当大的诊断价值。
