东非狒狒（阿拉伯狒狒）中的基因定位与同线群

Gene assignments and syntenic groups in the sacred baboon (Papio hamadryas).

作者信息

Thiessen K M, Lalley P A

出版信息

Cytogenet Cell Genet. 1987;44(2-3):82-8. doi: 10.1159/000132348.

Abstract

Eighteen genes were assigned to chromosomes in the sacred baboon, Papio hamadryas, by their concordant segregation with the chromosomes in a set of baboon X Chinese hamster somatic cell hybrids. ACY1 was assigned to P. hamadryas chromosome 2 (PHA 2); SOD1 and MDH2 to PHA 3; ME1 and SOD2 to PHA 4; NP, MPI, PKM2, and HEXA to PHA 7; PP to PHA 9; ADA and ITPA to PHA 10; LDHB and TPI1 to PHA 11; MDH1 to PHA 13; ESD to PHA 17; and GPI and PEPD to PHA 20. Regional assignments were possible for ACY1 (PHA 2pter----q1) and MDH2 and SOD1 (PHA 3p). Five other independently segregating markers or syntenic groups (PGD, PGM1; and PEPC; PGM2 and PEPS; IDH1; LDHA and ACP2; and GSR) were also identified. Gene assignments and syntenic groups described in P. hamadryas are compared to those found in P. papio, the rhesus monkey, and man. A possible primate model for human lymphoid disease is discussed.

摘要

通过一组狒狒与中国仓鼠体细胞杂种中的染色体的一致分离，在阿拉伯狒狒（Papio hamadryas）中确定了18个基因的染色体定位。ACY1定位于阿拉伯狒狒2号染色体（PHA 2）；SOD1和MDH2定位于PHA 3；ME1和SOD2定位于PHA 4；NP、MPI、PKM2和HEXA定位于PHA 7；PP定位于PHA 9；ADA和ITPA定位于PHA 10；LDHB和TPI1定位于PHA 11；MDH1定位于PHA 13；ESD定位于PHA 17；GPI和PEPD定位于PHA 20。ACY1（PHA 2pter----q1）、MDH2和SOD1（PHA 3p）可以进行区域定位。还鉴定了其他五个独立分离的标记或同线群（PGD、PGM1；和PEPC；PGM2和PEPS；IDH1；LDHA和ACP2；以及GSR）。将阿拉伯狒狒中描述的基因定位和同线群与在豚尾狒狒、恒河猴和人类中发现的进行了比较。讨论了一种可能的人类淋巴疾病灵长类动物模型。