Department of Thoracic Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Shantou University Medical College, Shantou, China.
Hum Vaccin Immunother. 2021 Dec 2;17(12):5016-5023. doi: 10.1080/21645515.2021.1992212. Epub 2021 Oct 29.
Patients highly vulnerable for COVID-19 infection have been proposed to take priority for vaccination. However, vaccine hesitancy is usually more prevalent in these patients. Investigation around modifiable contributors of vaccine hesitancy plays a pivotal role in the formulation of coping strategies. We aimed to evaluate the impact of vaccine misconception in patients with lung cancer or pulmonary ground-glass opacity (GGO). A web-based questionnaire was constructed based on a qualitative interview with 15 patients and reviewed by a multidisciplinary expert panel. Six Likert five-scale questions were used to generate a score of vaccine misconception (SoVM), which ranged from 0 to 24 points, with a higher score indicating a higher level of misconception. A total of 61.6% (324/526) patients responded to our questionnaire. A higher proportion of low willingness patients (n = 173), compared to high willingness patients (n = 151), disagreed that cancer patients should be prioritized for COVID-19 vaccination (82.1% vs. 50.3%, < .001) and perceived themselves to have contraindications (45.7% vs. 15.9%, < .001). The mean SoVM was significantly lower in the high willingness group than the low willingness group (9.9 vs. 13.0, < .001). Among the unvaccinated patients, the SoVM increased as the willingness to be vaccinated decreased ( < .0001). In multivariable logistic regression, patients with higher SoVM (OR 0.783, 95% CI 0.722-0.848), being female (OR 0.531, 95% CI 0.307-0.918) or diagnosed with lung cancer (OR 0.481, 95% CI 0.284-0.814) were independently associated with a lower willingness to be vaccinated against COVID-19. Receiver operating characteristic curve suggested that a SoVM of 11 yielded the best discrimination for predicting the willingness to receive COVID-19 vaccine (AUC = 0.724). The study findings reveal that patient misconception significantly contributes to vaccine hesitancy and needs to be addressed by evidence-based education tailored to their specific concerns.
高危 COVID-19 感染人群被提议优先接种疫苗。然而，这些患者通常更倾向于对接种疫苗犹豫不决。调查可改变的疫苗犹豫因素在制定应对策略方面起着关键作用。我们旨在评估肺癌或肺部磨玻璃影 (GGO) 患者疫苗误解的影响。根据对 15 名患者的定性访谈，我们构建了一个基于网络的问卷，并由一个多学科专家小组进行了审查。六个李克特五分制问题用于生成疫苗误解评分 (SoVM)，分数范围为 0 至 24 分，得分越高表示误解程度越高。共有 61.6%（324/526）的患者回答了我们的问卷。与高意愿患者（n=151）相比，低意愿患者（n=173）更不同意癌症患者应优先接种 COVID-19 疫苗（82.1%对 50.3%，<0.001），并且认为自己有禁忌症（45.7%对 15.9%，<0.001）。高意愿组的平均 SoVM 明显低于低意愿组（9.9 对 13.0，<0.001）。在未接种疫苗的患者中，随着接种意愿的降低，SoVM 增加（<0.0001）。在多变量逻辑回归中，SoVM 较高的患者（OR 0.783，95%CI 0.722-0.848）、女性（OR 0.531，95%CI 0.307-0.918）或被诊断为肺癌的患者（OR 0.481，95%CI 0.284-0.814）与对 COVID-19 疫苗接种的意愿较低独立相关。接收者操作特征曲线表明，SoVM 为 11 时，预测接种 COVID-19 疫苗的意愿具有最佳的区分能力（AUC=0.724）。研究结果表明，患者误解显著导致疫苗犹豫，需要针对他们的具体问题进行基于证据的教育。
