Motter W, Ralph G, Lichtenegger W, Haas J
Geburtshilfe Frauenheilkd. 1987 Feb;47(2):113-6. doi: 10.1055/s-2008-1035788.
Between 1982 and 1984, at Graz University Obstetric and Gynaecological Clinic, labour was induced in 307 women (146 primiparae and 161 multiparae) by intravaginal administration of 3 mg prostaglandin (PG) E2 tablets, because birth was overdue or because labour was irregular. No risk factors were present when PG was administered: signs of deficiency or postmaturity, or twisted cord, were ruled out. The following complications were evaluated: birth rate and induction-birth interval in relation to cervical maturity and parity. The number of complications was low. It was unrelated to cervical maturity and only partially to parity. Birth was induced successfully with a single dose of 3 mg PG E2 in over 80% of the primiparae and over 90% of the multiparae. The majority of the primiparae and all the remaining multiparae were successfully delivered with a second dose; no relationship between birth rate and cervical maturity was established. Among the primiparae with a low degree of cervical maturity the child was born within 12 hours in over 50% of the cases, among primiparae with more mature cervices in almost 90%. Among the multiparae, the child was born within 12 hours in 90% of the cases regardless of the state of cervical maturity. It is concluded from these results that with appropriate monitoring of birth, intravaginal administration of PG E2 tablets is an efficient and easily managed method of inducing birth at term, involving little risk.
1982年至1984年间，在格拉茨大学妇产科诊所，对307名妇女（146名初产妇和161名经产妇）进行了引产，通过阴道内给予3毫克前列腺素（PG）E2片剂，原因是过期妊娠或产程不规则。在给予PG时不存在风险因素：排除了胎儿生长受限、过期产或脐带扭转的迹象。对以下并发症进行了评估：与宫颈成熟度和产次相关的分娩率和引产至分娩间隔。并发症数量较少。它与宫颈成熟度无关，仅部分与产次有关。超过80%的初产妇和超过90%的经产妇单剂量3毫克PG E2引产成功。大多数初产妇和所有其余经产妇第二剂引产成功；未确定分娩率与宫颈成熟度之间的关系。在宫颈成熟度低的初产妇中，超过50%的病例在12小时内分娩，宫颈较成熟的初产妇中这一比例近90%。在经产妇中，无论宫颈成熟度如何，90%的病例在12小时内分娩。从这些结果得出结论：在适当的分娩监测下，阴道内给予PG E2片剂是一种有效且易于管理的足月引产方法，风险很小。
