Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Am J Reprod Immunol. 2022 Jan;87(1):e13508. doi: 10.1111/aji.13508. Epub 2021 Nov 11.
Recurrent pregnancy loss (RPL) is one of the most complex and challenging scenarios in reproductive medicine. New theories about the mechanisms behind RPL have recently emerged, highlighting the multifactorial nature of this serious pregnancy complication. Unfortunately, these preclinical observations are rarely validated in the human scenario, where treatment remains ineffective and empirical. New technologies such as organoids, organ-on-a-chip, and 3D printing can be used to characterize the molecular cross talk between the uterine environment with its unique inflammatory cells and the developing embryo. Understanding the mechanisms behind RPL and identifying mediators and effectors and validating these targets for prevention and therapy in humans will have a profound impact on women's health.
复发性流产（RPL）是生殖医学中最复杂和最具挑战性的情况之一。最近出现了关于 RPL 背后机制的新理论，强调了这种严重妊娠并发症的多因素性质。不幸的是，这些临床前观察结果很少在人类情况下得到验证，在人类情况下，治疗仍然是无效和经验性的。类器官、器官芯片和 3D 打印等新技术可用于描述子宫环境与其独特的炎症细胞和发育中的胚胎之间的分子串扰。了解 RPL 的机制，鉴定介质和效应物，并在人类中验证这些预防和治疗靶点，将对妇女健康产生深远影响。
