Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.
NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.
Aliment Pharmacol Ther. 2022 Feb;55(3):327-338. doi: 10.1111/apt.16673. Epub 2021 Oct 30.
New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC).
To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide data for adequately powering future studies in this area.
This collation brings together 29 studies including 954 participants (530 healthy, 54 diverticulosis, 255 IBS, 53 functional constipation, 12 cystic fibrosis, 15 Crohn's disease, 20 coeliac disease, 15 scleroderma) which have been carried out in a single centre using comparable study designs.
Fasting SBWC (mean 82 [SD 65] mL) shows high variability with a small decline with advancing age (healthy volunteers only; individual patient data). Fasting values are increased in untreated coeliac disease (202 [290] mL, P = 0.004). Post-prandial SBWC shows less intra-individual variability than fasting values in healthy volunteers. SBWC is increased by eating, most markedly by high fat meals but also by fibre, both viscous and particulate. Indigestible residue accumulates in late post-prandial period but empties soon after ingestion of a high calorie meal which produces a significant drop (by 50 [52] mL) in healthy volunteers. The associated fall in SBWC is abnormal in people with cystic fibrosis (SBWC reduced by 10 [121] mL, P = 0.002) and in people with irritable bowel syndrome with diarrhoea (SBWC reduced by 17 [43] mL, P = 0.007).
SBWC as assessed by MRI is a valuable biomarker indicating the balance of secretion and absorption in health and disease and the impact of treatments.
磁共振成像（MRI）的新发展使得能够无创、准确地测量小肠含水量（SBWC）。
整理测量摄入各种食物后 SBWC 的研究，为该领域未来的研究提供足够的动力。
本研究汇集了 29 项研究，共纳入 954 名参与者（530 名健康人，54 名憩室病患者，255 名肠易激综合征患者，53 名功能性便秘患者，12 名囊性纤维化患者，15 名克罗恩病患者，20 名乳糜泻患者，15 名硬皮病患者），这些研究均在单一中心进行，采用可比的研究设计。
空腹 SBWC（平均值 82 [标准差 65] mL）具有很高的变异性，随着年龄的增长略有下降（仅健康志愿者；个体患者数据）。未经治疗的乳糜泻患者空腹 SBWC 升高（202 [290] mL，P = 0.004）。与空腹值相比，健康志愿者餐后 SBWC 的个体内变异性较小。进食后 SBWC 增加，高脂肪餐增加最明显，但纤维也会增加，无论是粘性纤维还是颗粒性纤维。在餐后晚期，未消化的残渣会积累，但在摄入高热量餐后会迅速排空，导致健康志愿者 SBWC 显著下降（下降 50 [52] mL）。囊性纤维化患者 SBWC 的下降（下降 10 [121] mL，P = 0.002）和腹泻型肠易激综合征患者 SBWC 的下降（下降 17 [43] mL，P = 0.007）异常。
MRI 评估的 SBWC 是一种有价值的生物标志物，可指示健康和疾病状态下分泌和吸收的平衡以及治疗的影响。
