• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The NLRP3 inflammasome inhibitor, OLT1177 , ameliorates experimental allergic asthma in mice.

作者信息

Lunding Lars P, Skouras Damaris B, Vock Christina, Dinarello Charles A, Wegmann Michael

机构信息

Division of Asthma Exacerbation & Regulation, Priority Area Asthma & Allergy, Research Center Borstel- Leibniz Lung Center, Borstel, Germany.

Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Marburg, Germany.

出版信息

Allergy. 2022 Mar;77(3):1035-1038. doi: 10.1111/all.15164. Epub 2021 Nov 10.

DOI:10.1111/all.15164
PMID:34716997
Abstract
摘要

相似文献

1
The NLRP3 inflammasome inhibitor, OLT1177 , ameliorates experimental allergic asthma in mice.NLRP3炎性小体抑制剂OLT1177可改善小鼠实验性变应性哮喘。
Allergy. 2022 Mar;77(3):1035-1038. doi: 10.1111/all.15164. Epub 2021 Nov 10.
2
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.OLT1177，一种β-磺酰基腈化合物，在人体中安全，可抑制 NLRP3 炎性小体并逆转炎症的代谢代价。
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29.
3
The NLRP3 inhibitor, OLT1177 attenuates brain injury in experimental intracerebral hemorrhage.NLRP3 抑制剂 OLT1177 可减轻实验性脑出血引起的脑损伤。
Int Immunopharmacol. 2024 Apr 20;131:111869. doi: 10.1016/j.intimp.2024.111869. Epub 2024 Mar 15.
4
Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury.OLT1177 抑制 NLRP3 炎性小体可在脊髓损伤后诱导功能保护和髓鞘保存。
Exp Neurol. 2022 Jan;347:113889. doi: 10.1016/j.expneurol.2021.113889. Epub 2021 Oct 12.
5
OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis.OLT1177（达帕努司他），一种选择性 NLRP3 炎性体抑制剂，可改善实验性自身免疫性脑脊髓炎发病机制。
Front Immunol. 2019 Nov 1;10:2578. doi: 10.3389/fimmu.2019.02578. eCollection 2019.
6
Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177 (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction.在因未再灌注前壁心肌梗死导致的严重缺血性心肌病小鼠模型中，通过用OLT1177（达潘舒特rile）抑制NLRP3炎性小体来保留收缩储备和舒张功能。
Molecules. 2021 Jun 9;26(12):3534. doi: 10.3390/molecules26123534.
7
The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse.NLRP3 炎性小体抑制剂 OLT1177（达帕那肽）可减少小鼠缺血再灌注损伤后的梗死面积并维持收缩功能。
J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222. doi: 10.1097/FJC.0000000000000658.
8
BBG enhances OLT1177-induced NLRP3 inflammasome inactivation by targeting P2X7R/NLRP3 and MyD88/NF-κB signaling in DSS-induced colitis in rats.BBG 通过靶向 P2X7R/NLRP3 和 MyD88/NF-κB 信号通路增强 OLT1177 诱导的 NLRP3 炎症小体失活，在 DSS 诱导的大鼠结肠炎中。
Life Sci. 2021 Apr 1;270:119123. doi: 10.1016/j.lfs.2021.119123. Epub 2021 Feb 3.
9
Inhibition of NLRP3 inflammasome attenuates spinal cord injury-induced lung injury in mice.NLRP3 炎性小体的抑制可减轻小鼠脊髓损伤诱导的肺损伤。
J Cell Physiol. 2019 May;234(5):6012-6022. doi: 10.1002/jcp.27233. Epub 2018 Dec 27.
10
BAY 11-7082 inhibits the NF-κB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis.BAY 11-7082抑制核因子κB（NF-κB）和NLRP3炎性小体途径，并对咪喹莫特诱导的银屑病具有保护作用。
Clin Sci (Lond). 2017 Mar 1;131(6):487-498. doi: 10.1042/CS20160645. Epub 2017 Jan 17.

引用本文的文献

1
Reprogramming Atherosclerosis: Precision Drug Delivery, Nanomedicine, and Immune-Targeted Therapies for Cardiovascular Risk Reduction.重塑动脉粥样硬化：精准药物递送、纳米医学与免疫靶向疗法以降低心血管风险
Pharmaceutics. 2025 Aug 7;17(8):1028. doi: 10.3390/pharmaceutics17081028.
2
Modelling the ageing dependence of cancer evolutionary trajectories.模拟癌症进化轨迹的衰老依赖性。
Nat Rev Cancer. 2025 Jul 10. doi: 10.1038/s41568-025-00838-3.
3
Proinflammatory Cytokines in Chronic Respiratory Diseases and Their Management.慢性呼吸道疾病中的促炎细胞因子及其管理
Cells. 2025 Mar 9;14(6):400. doi: 10.3390/cells14060400.
4
Fibroblast Growth Factor 21 Confers Protection Against Asthma Through Inhibition of NLRP3 Inflammasome Activation.成纤维细胞生长因子21通过抑制NLRP3炎性小体激活对哮喘具有保护作用。
Inflammation. 2024 Dec 27. doi: 10.1007/s10753-024-02222-z.
5
MiR-146a-5p engineered hucMSC-derived extracellular vesicles attenuate -induced allergic airway epithelial cell inflammation.miR-146a-5p 工程化 hucMSC 衍生的细胞外囊泡减轻 - 诱导的过敏性气道上皮细胞炎症。
Front Immunol. 2024 Sep 19;15:1443166. doi: 10.3389/fimmu.2024.1443166. eCollection 2024.
6
The NLRP3 inflammasome in allergic diseases: mechanisms and therapeutic implications.NLRP3 炎性小体在过敏性疾病中的作用机制及治疗意义。
Clin Exp Med. 2024 Sep 26;24(1):231. doi: 10.1007/s10238-024-01492-z.
7
Unraveling the role of NLRP3 inflammasome in allergic inflammation: implications for novel therapies.解析 NLRP3 炎性小体在过敏性炎症中的作用：对新型治疗方法的启示。
Front Immunol. 2024 Jul 26;15:1435892. doi: 10.3389/fimmu.2024.1435892. eCollection 2024.
8
An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammation.抗白细胞介素-1 受体 7 抗体可保护小鼠免受 LPS 诱导的组织和全身炎症。
Front Immunol. 2024 Jun 25;15:1427100. doi: 10.3389/fimmu.2024.1427100. eCollection 2024.
9
Targeting NLRP3 Inflammasome: Structure, Function, and Inhibitors.靶向 NLRP3 炎性小体：结构、功能和抑制剂。
Curr Med Chem. 2024;31(15):2021-2051. doi: 10.2174/0109298673289984231127062528.
10
Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases.PANoptosis 的机制及相关的小分子化合物在疾病治疗中的应用。
Cell Death Dis. 2023 Dec 21;14(12):851. doi: 10.1038/s41419-023-06370-2.