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解析 NLRP3 炎性小体在过敏性炎症中的作用：对新型治疗方法的启示。

Unraveling the role of NLRP3 inflammasome in allergic inflammation: implications for novel therapies.

机构信息

Zhuhai Campus of Zunyi Medical University, Zhuhai, China.

Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research, Shenzhen, China.

出版信息

Front Immunol. 2024 Jul 26;15:1435892. doi: 10.3389/fimmu.2024.1435892. eCollection 2024.

DOI:10.3389/fimmu.2024.1435892
PMID:39131161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11310156/
Abstract

Allergic diseases like asthma, allergic rhinitis and dermatitis pose a significant global health burden, driving the search for novel therapies. The NLRP3 inflammasome, a key component of the innate immune system, is implicated in various inflammatory diseases. Upon exposure to allergens, NLRP3 undergoes a two-step activation process (priming and assembly) to form active inflammasomes. These inflammasomes trigger caspase-1 activation, leading to the cleavage of pro-inflammatory cytokines (IL-1β and IL-18) and GSDMD. This process induces pyroptosis and amplifies inflammation. Recent studies in humans and mice strongly suggest a link between the NLRP3 inflammasome, IL-1β, and IL-18, and the development of allergic diseases. However, further research is needed to fully understand NLRP3's specific mechanisms in allergies. This review aims to summarize the latest advances in NLRP3 activation and regulation. We will discuss small molecule drugs and natural products targeting NLRP3 as potential therapeutic strategies for allergic diseases.

摘要

过敏疾病，如哮喘、过敏性鼻炎和皮炎，给全球健康带来重大负担，促使人们寻找新的治疗方法。NLRP3 炎性小体作为先天免疫系统的关键组成部分，与各种炎症性疾病有关。在接触过敏原后，NLRP3 经历两步激活过程（预激活和组装）形成活性炎性小体。这些炎性小体触发半胱天冬酶-1 的激活，导致促炎细胞因子（IL-1β 和 IL-18）和 GSDMD 的切割。这一过程诱导细胞焦亡并放大炎症。人类和小鼠的最近研究强烈表明 NLRP3 炎性小体、IL-1β 和 IL-18 与过敏疾病的发展之间存在关联。然而，仍需要进一步研究以充分了解 NLRP3 在过敏反应中的具体机制。本综述旨在总结 NLRP3 激活和调节的最新进展。我们将讨论针对 NLRP3 的小分子药物和天然产物作为治疗过敏疾病的潜在治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11310156/fcbeaf0653f9/fimmu-15-1435892-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11310156/448db24e7280/fimmu-15-1435892-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11310156/4ce37aba92f0/fimmu-15-1435892-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11310156/92a54998e38a/fimmu-15-1435892-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11310156/fcbeaf0653f9/fimmu-15-1435892-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11310156/448db24e7280/fimmu-15-1435892-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11310156/4ce37aba92f0/fimmu-15-1435892-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11310156/92a54998e38a/fimmu-15-1435892-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11310156/fcbeaf0653f9/fimmu-15-1435892-g004.jpg

相似文献

[1]
Unraveling the role of NLRP3 inflammasome in allergic inflammation: implications for novel therapies.

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[2]
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引用本文的文献

[1]
Contribution of NLRP3-GSDMD axis to PDGF-BB-induced vascular smooth muscle cell phenotypic transition.

Am J Physiol Cell Physiol. 2025-8-1

[2]
Mechanisms and Targeted Therapeutic Strategies in Sepsis-Induced Myocardial Dysfunction: The Role of NLRP3 Inflammasome-Mediated Inflammation.

J Inflamm Res. 2025-7-5

[3]
Inflammasome pathways in atopic dermatitis: insights into inflammatory mechanisms and therapeutic targets.

An Bras Dermatol. 2025-6-23

[4]
PGC-1α agonist ZLN005 ameliorates OVA-induced asthma in BALB/c mice through modulating the NF-κB-p65/NLRP3 pathway.

Iran J Basic Med Sci. 2025

[5]
Integrated bioinformatics analysis of biomarkers and pathways to explore the mechanisms and molecular targets related to allergic rhinitis and pyroptosis.

Sci Rep. 2025-4-30

[6]
Senegenin ameliorates diabetic encephalopathy via promoting mitophagy and repressing NLRP3 inflammasome activation.

Psychopharmacology (Berl). 2025-4-26

[7]
Interleukin 8 Molecular Interplay in Allergic Rhinitis and Chronic Rhinosinusitis with Nasal Polyps: A Scoping Review.

Life (Basel). 2025-3-15

本文引用的文献

[1]
The Neglected Sibling: NLRP2 Inflammasome in the Nervous System.

Aging Dis. 2024-5-7

[2]
Allergens induce upregulated IL-18 and IL-18Rα expression in blood Th2 and Th17 cells of patients with allergic asthma.

Clin Exp Immunol. 2024-6-20

[3]
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation.

Sci Signal. 2024-4-2

[4]
Immunomodulation in allergic rhinitis: Insights from Th2 cells and NLRP3/IL-18 pathway.

Cell Biochem Funct. 2024-4

[5]
Mahuang Fuzi Xixin decoction alleviates allergic rhinitis by inhibiting NLRP3/Caspase-1/GSDMD-N-mediated pyroptosis.

J Ethnopharmacol. 2024-6-12

[6]
IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress.

Redox Biol. 2024-5

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Protopine ameliorates OVA-induced asthma through modulatingTLR4/MyD88/NF-κB pathway and NLRP3 inflammasome-mediated pyroptosis.

Phytomedicine. 2024-4

[8]
Involvement and repair of epithelial barrier dysfunction in allergic diseases.

Front Immunol. 2024

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The role of NLRP3 inflammasome in type 2 inflammation related diseases.

Autoimmunity. 2024-12

[10]
Exposure of nonylphenol promoted NLRP3 inflammasome and GSDMD-mediated pyroptosis in allergic rhinitis mice.

Food Chem Toxicol. 2024-2

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