Solitary cutaneous metastasis from an ovarian high-grade serous carcinoma at the initial presentation: Cytologic diagnosis of a rare manifestation.

Cutaneous metastasis can rarely be the first manifestation of visceral malignancies and is commonly seen in advanced-stage malignancies. It is infrequently seen in patients with ovarian malignancies and may develop either late in the course of the disease or at the initial presentation. Such cases are often associated with poor prognosis, and a prompt, precise tissue diagnosis is essential for appropriate patient management and better clinical outcome. Herein, we present a case of cutaneous metastasis in a young woman with an undiagnosed abdominopelvic mass that was diagnosed as metastatic high-grade serous carcinoma (HGSC) on fine-needle aspiration cytology (FNAC) supplemented by immunocytochemistry (ICC) on the cell block. The index case documents a unique and rare metastatic presentation of ovarian HGSC, as non-Sister Mary Joseph anterior abdominal wall nodule, at the initial presentation. Additionally, it highlights the utility of minimally-invasive FNA combined with ICC in prompt and accurate preoperative diagnosis of an underlying ovarian malignancy.