Department of Pathology, IMS and SUM Hospital, Siksha "O" Anusandhan University (Deemed to be), K8, Kalinganagar, Bhubaneswar, Odisha, India.
Indian J Pathol Microbiol. 2023 Jul-Sep;66(3):636-639. doi: 10.4103/ijpm.ijpm_561_21.
Metastasis from non-mammary malignant neoplasms to the breast is rare and represents 0.2%-1.3% of all breast malignancies. Fine needle aspiration cytology (FNAC) is the first line of investigation for any breast lump and cyto-morphological appearance of primary breast malignancies is well documented. Occasionally metastasis to the breast may be the initial presentation and can masquerade clinically as primary breast malignancy. The present case describes the clinical and cytological challenges in an unusual case of ovarian carcinoma with initial presentation as breast mass, mimicking as inflammatory carcinoma. In cytology the breast lesion was initially misdiagnosed as primary breast carcinoma and subsequently diagnosed as metastatic ovarian carcinoma based on core needle biopsy findings, aberrant immuno-profile and clinical findings; thus making the complex case worthy of discussion.
非乳腺恶性肿瘤转移至乳房的情况较为罕见,占所有乳腺恶性肿瘤的 0.2%-1.3%。细针穿刺细胞学检查(FNAC)是对任何乳腺肿块的一线检查方法,原发性乳腺恶性肿瘤的细胞形态学表现已有充分的文献记载。偶尔,转移至乳房可能是初始表现,并可能在临床上伪装为原发性乳腺恶性肿瘤。本病例描述了一例以乳腺肿块为首发表现的卵巢癌的临床和细胞学挑战,其表现类似于炎性癌。在细胞学上,乳腺病变最初被误诊为原发性乳腺癌,随后根据核心针活检结果、异常免疫表型和临床发现诊断为转移性卵巢癌;因此,这个复杂的病例值得讨论。