Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia.
Sirius University of Science and Technology, 1 Olympic Ave, 354340, Sochi, Russia.
J Nanobiotechnology. 2021 Oct 30;19(1):354. doi: 10.1186/s12951-021-01100-2.
Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent decades, the fields of material science and nanomedicine have generated several delivery platforms with high potential for overcoming multiple barriers associated to oral administration. This review describes the properties of several nanodelivery systems that improve the bioavailability of orally administered therapeutics, highlighting their advantages and disadvantages in generating successful anticancer oral nanomedicines.
口服给药是一种很有吸引力的癌症治疗途径。然而，胃肠道具有特定且高效的物理、化学和生物屏障，这些屏障会降低药物（包括化疗药物）的生物利用度。在最近几十年，材料科学和纳米医学领域已经产生了几种具有高潜力的递药平台，可以克服与口服给药相关的多种障碍。本综述描述了几种可提高口服治疗药物生物利用度的纳米递药系统的特性，重点介绍了它们在生成成功的抗癌口服纳米药物方面的优缺点。
