Department of Orthopedics, Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China.
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Arthritis Res Ther. 2021 Oct 30;23(1):277. doi: 10.1186/s13075-021-02662-0.
Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. Here, we reviewed the role of IGF-1 in cartilage anabolism and catabolism. Moreover, we discussed the potential role of IGF-1 in OA treatment. Of note, we summarized the recent progress on IGF delivery systems. Optimization of IGF delivery systems will facilitate treatment application in cartilage repair and improve OA treatment efficacy.
关节软骨修复是骨关节炎（OA）治疗的一个关键问题。胰岛素样生长因子（IGF）信号通路与关节软骨修复有关。IGF-1 是生长因子家族的一员，与前胰岛素结构上密切相关，可促进软骨细胞增殖，增强基质生成，抑制软骨细胞凋亡。在这里，我们综述了 IGF-1 在软骨合成代谢和分解代谢中的作用。此外，我们还讨论了 IGF-1 在 OA 治疗中的潜在作用。值得注意的是，我们总结了 IGF 传递系统的最新进展。优化 IGF 传递系统将有助于在软骨修复中应用治疗，并提高 OA 治疗效果。
