The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, 250014, China.
Department of Cardiology, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, 250001, China.
Peptides. 2022 Jan;147:170674. doi: 10.1016/j.peptides.2021.170674. Epub 2021 Oct 28.
For a long time, Apelin has been considered as the only endogenous ligand of G protein-coupled receptor APJ. Until recently, the discovery of Elabela (Apela/Toddler) as a new polypeptide that can act through APJ and has a similar function to Apelin broke this situation. Elabela promotes a variety of cell proliferation processes, including embryonic development, and has especially beneficial effects in the cardiovascular system. In this review, we summarize the biological functions of Elabela and review its specific roles in cardiovascular diseases and the signaling pathways mediated by it.
长期以来，Apelin 一直被认为是 G 蛋白偶联受体 APJ 的唯一内源性配体。直到最近，Elabela（Apela/Toddler）作为一种新的多肽被发现，它可以通过 APJ 发挥作用，并且具有与 Apelin 相似的功能，打破了这种局面。Elabela 促进了多种细胞增殖过程，包括胚胎发育，并且在心血管系统中具有特别有益的作用。在这篇综述中，我们总结了 Elabela 的生物学功能，并回顾了它在心血管疾病中的具体作用及其介导的信号通路。
