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人正常和恶性淋巴细胞克隆形成细胞的体外细胞毒性药物敏感性

In vitro cytotoxic drug sensitivity of human normal and malignant lymphocyte-clone-forming cells.

作者信息

Matthews C, Kutlaca B, Seshadri R

出版信息

Int J Cell Cloning. 1987 Mar;5(2):149-57. doi: 10.1002/stem.5530050207.

DOI:10.1002/stem.5530050207
PMID:3471818
Abstract

Cytotoxic drug sensitivity of normal human lymphocytes and malignant lymphocytes was estimated by a clonogenic method. Malignant T and B lymphocytes were relatively more sensitive than normal T lymphocytes to vincristine and Adriamycin. Since no plateau was observed in the clone survival with associated increasing drug concentration, spontaneous mutants could not be detected. It is suggested that the resistance to "natural product" drugs such as vincristine arises from induced mutations and not from the selection of already existing spontaneous mutants.

摘要

采用克隆形成法评估正常人淋巴细胞和恶性淋巴细胞的细胞毒性药物敏感性。恶性T淋巴细胞和B淋巴细胞对长春新碱和阿霉素的敏感性相对高于正常T淋巴细胞。由于随着药物浓度增加克隆存活率未出现平台期，因此未检测到自发突变体。提示对长春新碱等“天然产物”药物的耐药性源于诱导突变，而非已有自发突变体的选择。

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