Department for Functional Genomics, Center for Translational and Clinical Research, University of Zagreb, School of Medicine, Šalata 2, 10000 Zagreb, Croatia,
Psychiatr Danub. 2021 Spring-Summer;33(Suppl 4):456-462.
Parkinson's disease (PD) is a neurodegenerative disorder clinically characterized by motor dysfunctions due to progressive loss of dopaminergic neurons and a broad spectrum of non-motor symptoms. Interestingly, non-motor symptoms like depression, anxiety and psychosis are often present several years before the occurrence of classic motor features seriously affecting patient quality of life. Their presence is often misleading, delaying the correct diagnosis of PD. Despite its high incidence, the pathophysiology and aetiology of neuropsychiatric symptoms associated with PD remains unclear. Currently, a lot of interest lays in research looking for genetic predictors of motor and non-motor symptoms in PD. The availability of next-generation sequencing technology for genome, epigenetic and transcriptional analysis opens the door to a new way of studying multifactorial diseases like PD and their comorbidities. In this review we will present new insights in the genomic and epigenetic background of psychiatric comorbidity in Parkinson's disease.
帕金森病（PD）是一种神经退行性疾病，临床上以多巴胺能神经元进行性丧失为特征，导致运动功能障碍，并伴有广泛的非运动症状。有趣的是，抑郁、焦虑和精神病等非运动症状常在经典运动特征出现前数年出现，严重影响患者的生活质量。其存在常常具有误导性，导致 PD 的正确诊断被延误。尽管发病率很高，但与 PD 相关的神经精神症状的病理生理学和病因仍不清楚。目前，人们对寻找 PD 运动和非运动症状的遗传预测因子很感兴趣。新一代测序技术可用于基因组、表观遗传和转录组分析，为研究 PD 及其合并症等多因素疾病开辟了新途径。在这篇综述中，我们将介绍帕金森病伴发精神障碍的基因组和表观遗传学背景的新见解。
