Inserm UMR_S1256 Nutrition-Genetics-Environmental Risk Exposure, University of Lorraine, 54500 Nancy, France.
FHU ARRIMAGE, department of Biochemistry-Molecular Biology-Nutrition, University Hospital Centre of Nancy, 54500 Nancy, France.
J Clin Endocrinol Metab. 2022 Feb 17;107(3):e1074-e1084. doi: 10.1210/clinem/dgab774.
A recent study identified 14 low-frequency coding variants associated with body mass index (BMI) in 718 734 individuals predominantly of European ancestry.
We investigated the association of 2 genetic scores (GS) with i) the risk of severe/morbid obesity, ii) BMI variation before weight-loss intervention, iii) BMI change in response to an 18-month lifestyle/behavioral intervention program, and iv) BMI change up to 24 months after bariatric surgery.
The 14 low-frequency coding variants were genotyped or sequenced in 342 French adults with severe/morbid obesity and 574 French adult controls from the general population. We built risk and protective GS based on 6 BMI-increasing and 5 BMI-decreasing low-frequency coding variants that were polymorphic in our study.
While the risk GS was not associated with severe/morbid obesity status, BMI-decreasing low-frequency coding variants were significantly less frequent in patients with severe/morbid obesity than in French adults from the general population. Neither the risk nor the protective GS was associated with BMI before intervention in patients with severe/morbid obesity, nor did they affect BMI change in response to a lifestyle/behavioral modification program. The protective GS was associated with a greater BMI decrease following bariatric surgery. The risk and protective GS were associated with a higher and lower risk of BMI regain after bariatric surgery.
Our data indicate that in populations of European descent, low-frequency coding variants associated with BMI in the general population also affect the outcomes of bariatric surgery in patients with severe/morbid obesity.
最近的一项研究在主要为欧洲血统的 718734 个人中确定了 14 个与体重指数（BMI）相关的低频编码变异。
我们研究了 2 个遗传评分（GS）与以下方面的关联：i）严重/病态肥胖的风险，ii）减肥干预前的 BMI 变化，iii）对 18 个月生活方式/行为干预计划的 BMI 变化，以及 iv）减肥手术后 24 个月的 BMI 变化。
在 342 名患有严重/病态肥胖的法国成年人和 574 名来自普通人群的法国成年人对照中，对 14 个低频编码变异进行了基因分型或测序。我们基于在我们的研究中多态性的 6 个 BMI 增加和 5 个 BMI 减少的低频编码变异构建了风险和保护 GS。
虽然风险 GS 与严重/病态肥胖状态无关，但在患有严重/病态肥胖的患者中，BMI 减少的低频编码变异明显少于普通人群中的法国成年人。在患有严重/病态肥胖的患者中，风险和保护 GS 都与干预前的 BMI 无关，也不影响对生活方式/行为修正计划的 BMI 变化。保护 GS 与减肥手术后 BMI 的更大减少相关。风险和保护 GS 与减肥手术后 BMI 恢复的风险增加和降低相关。
我们的数据表明，在欧洲血统的人群中，与普通人群 BMI 相关的低频编码变异也会影响严重/病态肥胖患者减肥手术的结果。
