Eye Clinic Sulzbach, Knappschaft Hospital Saar, An der Klinik 10, 66280, Sulzbach, Germany.
Klaus Heimann Eye Research Institute (KHERI), Knappschaft Hospital Saar, Sulzbach, Germany.
Int Ophthalmol. 2022 Apr;42(4):1061-1068. doi: 10.1007/s10792-021-02091-7. Epub 2021 Oct 31.
Evaluating the effect of a single peripheral triangular mark to ensure the correct anterior-posterior graft orientation in DMEK.
Retrospective study of patients scheduled for DMEK due to Fuchs endothelial dystrophy and divided into 2 study groups: Group -M (n = 184) had no mark of the EDM (Endothelial Descemet membrane) and group + M (n = 193) had a triangular peripheral mark. Follow-up time was 1 year after surgery.
The postoperative graft turning and Re-DMEK rate could be significantly reduced by the use of a peripheral mark (p = 0.002, p = 0.001, respectively). Re-DMEK due to primary graft failure was significantly associated with prior graft turning (p < 0.001). Both groups showed comparable values for visual acuity, central corneal thickness and endothelial cell count after a follow-up of 1 year.
Single peripheral triangular marking is a simple and cost-saving addition to EDM preparation to ensure the correct orientation of the graft intraoperatively and could lead to a significant reduction in graft turning and re-DMEK rate in this study.
评估单个周边三角标记对确保 DMEK 中正确前后移植方位的效果。
回顾性研究因 Fuchs 内皮营养不良而接受 DMEK 治疗的患者，并分为 2 个研究组：-M 组（n=184）无 EDM（内皮 Descemet 膜）标记，+M 组（n=193）有周边三角标记。术后随访时间为 1 年。
使用周边标记可显著降低术后移植物旋转和重新 DMEK 率（p=0.002，p=0.001）。初次移植物失败导致的重新 DMEK 与先前的移植物旋转显著相关（p<0.001）。在 1 年的随访后，两组的视力、中央角膜厚度和内皮细胞计数均具有可比的值。
在 EDM 准备中添加单个周边三角标记是一种简单且节省成本的方法，可以确保术中移植物的正确方位，并可能导致本研究中转植率和重新 DMEK 率显著降低。
