脑内细胞治疗的传递策略：克服多重障碍。
Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers.
机构信息
Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, VA, USA.
Department of Computational and Quantitative Medicine, Division of Mathematical Oncology, City of Hope, Duarte, CA, USA.
出版信息
Drug Deliv Transl Res. 2021 Dec;11(6):2448-2467. doi: 10.1007/s13346-021-01079-1. Epub 2021 Oct 30.
Cell-based therapies to the brain are promising for the treatment of multiple brain disorders including neurodegeneration and cancers. In order to access the brain parenchyma, there are multiple physiological barriers that must be overcome depending on the route of delivery. Specifically, the blood-brain barrier has been a major difficulty in drug delivery for decades, and it still presents a challenge for the delivery of therapeutic cells. Other barriers, including the blood-cerebrospinal fluid barrier and lymphatic-brain barrier, are less explored, but may offer specific challenges or opportunities for therapeutic delivery. Here we discuss the barriers to the brain and the strategies currently in place to deliver cell-based therapies, including engineered T cells, dendritic cells, and stem cells, to treat diseases. With a particular focus on cancers, we also highlight the current ongoing clinical trials that use cell-based therapies to treat disease, many of which show promise at treating some of the deadliest illnesses.
细胞疗法对大脑具有广阔的应用前景，可用于治疗多种脑部疾病，包括神经退行性疾病和癌症。为了到达脑组织，必须克服多种生理障碍，具体取决于输送途径。具体而言，血脑屏障几十年来一直是药物输送的主要难题，对于治疗细胞的输送仍然是一个挑战。其他屏障，包括血脑脊液屏障和淋巴脑屏障，研究较少，但可能为治疗性输送提供特定的挑战或机会。在这里，我们讨论了大脑的障碍以及目前用于输送细胞疗法的策略，包括工程化 T 细胞、树突状细胞和干细胞，以治疗疾病。特别关注癌症，我们还强调了目前正在进行的临床试验，这些试验使用细胞疗法来治疗疾病，其中许多试验在治疗某些最致命的疾病方面显示出了前景。
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