Wright G L, McCumbee W D, Broome T, Eaton S
J Hypertens Suppl. 1986 Dec;4(5):S145-7.
We have previously demonstrated the existence of an active component(s) of extracts prepared from rat erythrocytes that stimulates the in vitro uptake of calcium in aortic rings and induces a sustained elevation in the blood pressure of normotensive rats. The apparent concentration of the calcium stimulatory component and the responsiveness of aortic rings to stimulation of calcium uptake by the compound is exaggerated in adult spontaneously hypertensive rats (SHR) compared with normotensive controls. Although no effect was observed on tissue responsiveness to the compound, a decrease in the concentration of the compound was observed in the blood of adult SHR subjected to dietary manipulation designed to blunt the elevation of blood pressure. These data suggest that blood concentration of the active compound may be influenced by external stimuli such as dietary manipulation.
我们之前已经证明，从大鼠红细胞中制备的提取物存在一种活性成分，该成分可刺激主动脉环体外摄取钙，并使正常血压大鼠的血压持续升高。与正常血压对照组相比，成年自发性高血压大鼠（SHR）中钙刺激成分的表观浓度以及主动脉环对该化合物刺激钙摄取的反应性都有所增强。尽管未观察到该化合物对组织反应性有影响，但在接受旨在抑制血压升高的饮食干预的成年SHR血液中，该化合物的浓度有所降低。这些数据表明，活性化合物的血液浓度可能受到饮食干预等外部刺激的影响。
