Siegrist J, Matschinger H, Motz W
J Hypertens Suppl. 1987 Feb;5(1):S15-20.
Two groups of untreated and treated subjects with persistent manifest or borderline hypertension were identified within a prospective study on cardiovascular risk in 416 middle-aged male blue-collar workers. They were compared with respect to four dimensions of quality of life: physical symptoms, mental alertness, emotional well-being and work performance. Only one symptom (nocturnal sleep disturbances) was significantly less frequent in the untreated group. Whereas short-term benefit from drug refusal seems limited, long-term costs in terms of subclinical end-organ damage are considerable. Echocardiographic findings demonstrated early stages of left ventricular hypertrophy (LVH) in one-third of the subjects with persistent borderline hypertension. Considering the role of LVH in cardiovascular mortality, results suggest that we should reinforce diagnostic and therapeutic activities in subjects with persistent borderline hypertension.
在一项针对416名中年男性蓝领工人心血管风险的前瞻性研究中，确定了两组未经治疗和接受治疗的持续性显性或临界高血压患者。对他们在生活质量的四个维度进行了比较：身体症状、精神警觉性、情绪健康和工作表现。未经治疗组中只有一种症状（夜间睡眠障碍）出现的频率明显较低。虽然拒绝服药的短期益处似乎有限，但亚临床终末器官损害方面的长期代价相当大。超声心动图检查结果显示，三分之一持续性临界高血压患者存在左心室肥厚（LVH）的早期阶段。考虑到LVH在心血管死亡率中的作用，结果表明我们应该加强对持续性临界高血压患者的诊断和治疗活动。
