Ivko Tanya, Hrytsenko Vita, Kienko Lydmila, Bobrytska Larisa, Kukhtenko Halyna, Germanyuk Tamara
National Pirogov Memorial Medical University, Department of Pharmacy, Vinnytsya, Ukraine
National University of Pharmacy, Department of Industrial Technology of Drugs, Kharkiv, Ukraine
Turk J Pharm Sci. 2021 Oct 28;18(5):628-636. doi: 10.4274/tjps.galenos.2021.93457.
Combinatorial drugs are among the leading pharmacotherapeutic agents, including those used for the treatment of herpetic infections, which require complex treatment. We have developed a soft dosage form of ointment, which includes acyclovir and miramistin, which have antimicrobial, anti-inflammatory, and local immunoadjuvant activity. The study aimed to investigate the rheological properties of ointment bases in order to substantiate the composition of a soft dosage form with antiviral effect using the active ingredients miramistin and acyclovir.
The object of the study was to determine the heterogeneous and homogeneous composition models of the bases made using a wide range of excipients. Structural and mechanical studies were performed using the "Rheolab QC" rotary viscometer by Anton Paar (Austria) with coaxial cylinders CC27/S-SN29766. The rheological parameters were investigated at a temperature of 25°C±0.5°C. The samples were thermostated using a thermostat MLM U15c. The batch of sample weighing about 15.0±0.5 g was placed in the container of an external stationary cylinder. The required temperature of the experiment was set and the thermostating time was 20 min. The device is equipped with RheoPlus 32 V3.62 software.
The rheological behavior of the model compositions was analyzed in terms of indicators, such as yield strength, hysteresis square, coefficients of dynamic flow, and mechanical stability. It was found that all samples have a non-Newtonian pseudoplastic type of flow. The model of spreading optimums was used to evaluate consumer properties. According to the rheological parameters, it is advisable to use the sample based on paraffin and vaseline oil for further research.
The findings from this study will be relevant in the development of the soft dosage form for the treatment of herpes viral diseases.
复方药物是主要的药物治疗剂之一，包括用于治疗疱疹感染的药物，这类感染需要复杂的治疗。我们研发了一种软膏剂的软剂型，其中含有阿昔洛韦和咪喹莫特，它们具有抗菌、抗炎和局部免疫佐剂活性。本研究旨在研究软膏基质的流变学性质，以便用活性成分咪喹莫特和阿昔洛韦证实具有抗病毒作用的软剂型的组成。
本研究的目的是确定使用多种辅料制成的基质的非均相和均相组成模型。使用奥地利安东帕公司的“Rheolab QC”旋转粘度计和同轴圆筒CC27/S - SN29766进行结构和力学研究。在25°C±0.5°C的温度下研究流变学参数。使用MLM U15c恒温器对样品进行恒温处理。将约15.0±0.5 g的一批样品放入外部固定圆筒的容器中。设定所需的实验温度，恒温时间为20分钟。该设备配备RheoPlus 32 V3.62软件。
根据屈服强度、滞后平方、动态流动系数和机械稳定性等指标分析了模型组合物的流变行为。发现所有样品均具有非牛顿假塑性流动类型。使用铺展最佳模型来评估消费者性能。根据流变学参数，建议使用基于石蜡和凡士林油的样品进行进一步研究。
本研究结果将与治疗疱疹病毒性疾病的软剂型的开发相关。
