Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR,China.
Curr Alzheimer Res. 2021;18(10):831-840. doi: 10.2174/1567205018666211022164025.
Nitric oxide synthase (NOS) is well known for its involvement in the regulation of the nervous, cardiovascular, and immune systems. Neuronal NOS (nNOS) is the most characterized NOS among all the isoforms. It accounts for most of the production of nitric oxide (NO) in the nervous system required for synaptic transmission and neuroplasticity. Previous studies have described the localization of nNOS in specific brain regions of interest. There is substantial evidence in the literature suggesting that nNOS signaling has significant involvement in several disease pathologies. However, the association between brain nNOS expression profiles and disease remains largely unknown. In this review, we attempt to delineate the contribution of nNOS signaling in memory and mood disorders in order to achieve a better understanding of nNOS in disease modulation.
一氧化氮合酶（NOS）因其参与神经系统、心血管系统和免疫系统的调节而广为人知。神经元型 NOS（nNOS）是所有同工酶中最具特征的 NOS。它负责产生神经系统中大多数用于突触传递和神经可塑性的一氧化氮（NO）。先前的研究已经描述了 nNOS 在特定脑区的定位。文献中有大量证据表明，nNOS 信号在几种疾病病理中具有重要作用。然而，大脑中 nNOS 表达谱与疾病之间的关联在很大程度上仍然未知。在这篇综述中，我们试图描绘 nNOS 信号在记忆和情绪障碍中的作用，以便更好地理解 nNOS 在疾病调节中的作用。
