Maeda Masayuki, Miyake Takefumi, Inose Ryo, Ueda Satoru, Matsugi Ken-Ichi, Muraki Yuichi, Kitahara Takashi
Division of Infection Control Sciences, Department of Clinical Pharmacy, School of Pharmacy, Showa University, 1-4-5 Hatanodai, Shinagawa-ku, Tokyo, Japan.
Fourth Subcommittee, Committee on Academic, The Japanese Society of Hospital Pharmacists, Tokyo, Japan.
J Pharm Health Care Sci. 2021 Nov 1;7(1):38. doi: 10.1186/s40780-021-00223-w.
Pharmacist plays an integral role in promoting antimicrobial stewardship (AS) strategies by committing to the evidence-based activities in this field. The present study aims to document trends in actual achievements through bibliometric analysis and identify the future direction of pharmacists with expertise in AS by describing the characteristics of articles on AS written by Japanese pharmacists.
The study searched for articles written in Japanese and English on Ichushi-Web and MEDLINE, respectively, until December 2020 for published articles relevant to AS. The articles were classified into the seven groups according to content. Interrupted time series analysis (ITSA) was performed to identify the effect of the certification system for infection control pharmacy specialists (ICPSs) on the number of articles in Japanese.
The study retrieved 476 and 145 titles from Ichushi-Web and MEDLINE, respectively, out of which 383 and 123 articles written in Japanese and English, respectively, were considered relevant to AS. A continued publication was found for Japanese articles written by pharmacists assigned to large-sized hospitals since 1998, whereas few articles in English were published until 2017. The most frequent content of articles in both languages was intervention (56.7 and 59.0%, respectively). ITSA indicated that the number of publication slightly increased before [β1 = 1.33, 95% confidence interval (CI): - 0.62-3.28; P = 0.169] the implementation of the system. Moreover, the level (β2 = 11.41, 95%CI: - 0.23-23.05; P = 0.054) increased after the implementation of the system, whereas the slope decreased (β3 = - 2.07, 95%CI: - 4.16-0.03; P = 0.053). However, the changes were not statistically significant.
The study identified the contribution of pharmacists by documenting trends in AS practice and by conducting bibliometric analysis. The implementation of the ICPS certification system positively influenced the trend of publications. Therefore, the study recommends that policymakers and stakeholders should promote and support the evidence-based activities for AS for pharmacists in small- to medium-sized hospitals.
药剂师通过致力于该领域基于证据的活动，在促进抗菌药物管理（AS）策略方面发挥着不可或缺的作用。本研究旨在通过文献计量分析记录实际成果的趋势，并通过描述日本药剂师撰写的关于AS的文章的特征，确定具有AS专业知识的药剂师的未来发展方向。
该研究分别在Ichushi-Web和MEDLINE上搜索截至2020年12月撰写的与AS相关的日文和英文文章。根据内容将文章分为七组。进行中断时间序列分析（ITSA）以确定感染控制药学专家（ICPS）认证系统对日文文章数量的影响。
该研究分别从Ichushi-Web和MEDLINE中检索到476篇和145篇文章标题，其中分别有383篇日文文章和123篇英文文章被认为与AS相关。自1998年以来，发现大型医院的药剂师撰写的日文文章持续发表，而直到2017年英文文章发表较少。两种语言文章中最常见的内容都是干预（分别为56.7%和59.0%）。ITSA表明，在该系统实施之前，发表数量略有增加[β1 = 1.33，95%置信区间（CI）：-0.62-3.28；P = 0.169]。此外，该系统实施后水平有所提高（β2 = 11.41，95%CI：-0.23-23.05；P = 0.054），而斜率下降（β3 = -2.07，95%CI：-4.16-0.03；P = 0.053）。然而，这些变化没有统计学意义。
该研究通过记录AS实践趋势和进行文献计量分析，确定了药剂师的贡献。ICPS认证系统的实施对发表趋势产生了积极影响。因此，该研究建议政策制定者和利益相关者应促进和支持中小型医院药剂师基于证据的AS活动。
