Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Kastamonu, Kastamonu, Turkey.
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey.
J Vet Pharmacol Ther. 2022 Jan;45(1):126-132. doi: 10.1111/jvp.13027. Epub 2021 Oct 31.
The aim of the study was to determine the effect of ketoprofen (2 mg/kg) on the intravenous pharmacokinetics of ganciclovir (10 mg/kg) in chukar partridges (Alectoris chukar). Eight clinically healthy partridges were used in the study. The study was performed in two periods using a cross-over design following a 15-day drug washout period. Plasma concentrations of ganciclovir were determined using the high-pressure liquid chromatography-ultraviolet detector and analyzed by non-compartmental analysis. The elimination half-life (t ), area under the concentration-time curve (AUC ), total body clearance, and volume of distribution at steady state of ganciclovir were 1.63 h, 33.22 h*μg/ml, 0.30 L/h/kg, and 0.53 L/kg, respectively. Ketoprofen administration increased the t and AUC of ganciclovir by 78% and 108%, respectively, and while decreased Cl by 53%. The increased plasma concentration and prolonged elimination half-life of ganciclovir caused by ketoprofen may result in the prolonged duration of action and therapeutic effect of ganciclovir. However, the concomitant use requires determination of the pharmacokinetics of ketoprofen and the safety of both drugs.
本研究旨在确定酮洛芬（2mg/kg）对鹧鸪（Alectoris chukar）体内静脉注射更昔洛韦（10mg/kg）药代动力学的影响。本研究使用了 8 只临床健康的鹧鸪，采用交叉设计，在 15 天药物洗脱期后进行研究。使用高压液相色谱-紫外检测器测定更昔洛韦的血浆浓度，并采用非房室分析进行分析。更昔洛韦的消除半衰期（t ）、浓度-时间曲线下面积（AUC）、总清除率和稳态分布容积分别为 1.63h、33.22h*μg/ml、0.30L/h/kg 和 0.53L/kg。酮洛芬给药使更昔洛韦的 t 和 AUC 分别增加了 78%和 108%，同时使 Cl 降低了 53%。酮洛芬引起的更昔洛韦血浆浓度升高和消除半衰期延长可能导致更昔洛韦的作用持续时间和治疗效果延长。然而，两者合用需要确定酮洛芬的药代动力学和两种药物的安全性。
