Newland Pamela, Basan Yelyzaveta, Chen Ling, Wu Gregory
32989Goldfarb School of Nursing at Barnes-Jewish College, Saint Louis, MO, USA.
7548Washington University in St Louis, Saint Louis, MO, USA.
Biol Res Nurs. 2022 Jan;24(1):123-127. doi: 10.1177/10998004211050082. Epub 2021 Oct 31.
Multiple sclerosis (MS), an inflammatory neurodegenerative disease of the central nervous system (CNS), afflicts over one per thousand people in the United States. The pathology of MS typically involves lesions in several regions, including the brain and spinal cord. The manifestation of MS is variable and carries great potential to negatively impact quality of life (QOL). Evidence that inflammatory markers are related to depression in MS is accumulating. However, there are barriers in precisely identifying the biological mechanisms underlying depression and inflammation. Analysis of cytokines provides one promising approach for understanding the mechanisms that may contribute to MS symptoms.
In this pilot study, we measured salivary levels of interleukin (IL)-6, IL-1beta (β), and IL-10 in 24 veterans with MS. Descriptive statistics were reported and Pearson correlation coefficients were obtained between cytokines and depression.
The anti-inflammatory cytokine IL-10 was significantly negatively associated with depression in veterans with MS (r = -0.47, = .024).
Cytokines may be useful for elucidating biological mechanisms associated with the depression and a measure for nurses caring for veterans with MS.
多发性硬化症（MS）是一种中枢神经系统（CNS）的炎症性神经退行性疾病，在美国每千人中就有超过一人患病。MS的病理通常涉及多个区域的病变，包括大脑和脊髓。MS的表现具有多样性，对生活质量（QOL）有很大的负面影响。越来越多的证据表明，炎症标志物与MS患者的抑郁症有关。然而，在准确识别抑郁症和炎症背后的生物学机制方面存在障碍。细胞因子分析为理解可能导致MS症状的机制提供了一种有前景的方法。
在这项初步研究中，我们测量了24名患有MS的退伍军人唾液中白细胞介素（IL）-6、IL-1β（β）和IL-10的水平。报告了描述性统计数据，并获得了细胞因子与抑郁症之间的Pearson相关系数。
抗炎细胞因子IL-10与患有MS的退伍军人的抑郁症显著负相关（r = -0.47，P = 0.024）。
细胞因子可能有助于阐明与抑郁症相关的生物学机制，并且是护理患有MS的退伍军人的一项指标。
