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E-钙黏蛋白在沙特晚期上皮性卵巢癌患者中的预后价值及其肿瘤抑制作用。

Prognostic value of E-Cadherin and its tumor suppressor role in Saudi women with advanced epithelial ovarian cancer.

机构信息

Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

Medical Laboratory Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Saudi Arabia.

出版信息

Libyan J Med. 2021 Dec;16(1):1994741. doi: 10.1080/19932820.2021.1994741.

DOI:10.1080/19932820.2021.1994741
PMID:34720069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8567888/
Abstract

UNLABELLED

The extracellular matrix (ECM) disruption and cytoskeleton reorganization are crucial events in tumor proliferation and invasion. E-Cadherin (E-CAD) is a member of cell adhesion molecules involved in cell-cell junctions and ECM stability. The loss of E-CAD expression is associated with cancer progression and metastasis. This retrospective study aimed to assess E-CAD protein expression in ovarian cancer (OC) tissues and to evaluate its prognostic value.

PATIENTS AND METHODS

143 formalin-fixed and paraffin-embedded (FFPE) blocks of primary advanced stages OC were retrieved and used to construct Tissue microarrays. Automated immunohistochemistry technique was performed to evaluate E-CAD protein expression patterns in OC.

RESULTS

E-CAD protein expression was significantly correlated with OC histological subtype (p < 0.0001), while borderline significant correlations were observed with both tumor grade (p = 0.06) and stage (p = 0.07). Interestingly, Kaplan-Meier survival analysis showed that OC patients with membranous E-CAD expression survived longer than those with no E-CAD expression mainly those at advanced stages (p < 0.009). Further in silico analysis confirms the key roles of E-CAD in OC molecular functions.

CONCLUSION

we reported a prognosis value of membranous E-CAD in advanced stage OC patients. Further validation using larger cohorts is recommended to extract clinically relevant outcomes towards better OC management and individualized oncology.

摘要

未注明

细胞外基质（ECM）的破坏和细胞骨架的重组是肿瘤增殖和侵袭的关键事件。E-钙黏蛋白（E-CAD）是细胞黏附分子的成员，参与细胞-细胞连接和 ECM 的稳定性。E-CAD 表达的丧失与癌症的进展和转移有关。本回顾性研究旨在评估卵巢癌（OC）组织中 E-CAD 蛋白的表达，并评估其预后价值。

患者和方法

从 143 例福尔马林固定和石蜡包埋（FFPE）的原发性晚期 OC 组织块中检索并用于构建组织微阵列。采用自动化免疫组织化学技术评估 OC 中 E-CAD 蛋白的表达模式。

结果

E-CAD 蛋白表达与 OC 的组织学亚型显著相关（p<0.0001），与肿瘤分级（p=0.06）和分期（p=0.07）也有显著的相关性。有趣的是，Kaplan-Meier 生存分析显示，具有膜性 E-CAD 表达的 OC 患者比没有 E-CAD 表达的患者存活时间更长，主要是在晚期患者中（p<0.009）。进一步的计算分析证实了 E-CAD 在 OC 分子功能中的关键作用。

结论

我们报告了膜性 E-CAD 在晚期 OC 患者中的预后价值。建议使用更大的队列进行进一步验证，以提取对 OC 管理和个体化肿瘤学有临床意义的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6b/8567888/a53fdbc8a33e/ZLJM_A_1994741_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6b/8567888/c9ec21194e53/ZLJM_A_1994741_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6b/8567888/d31b85523832/ZLJM_A_1994741_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6b/8567888/cbebbf9e0ad6/ZLJM_A_1994741_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6b/8567888/a53fdbc8a33e/ZLJM_A_1994741_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6b/8567888/c9ec21194e53/ZLJM_A_1994741_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6b/8567888/d31b85523832/ZLJM_A_1994741_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6b/8567888/cbebbf9e0ad6/ZLJM_A_1994741_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6b/8567888/a53fdbc8a33e/ZLJM_A_1994741_F0004_OC.jpg

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