Matar Abraham J, Sachs David H, Duran-Struuck Raimon
Department of Surgery, Emory University School of Medicine, Atlanta, GA.
Department of Surgery, Columbia University Medical Center, New York, NY.
Transplantation. 2022 May 1;106(5):928-937. doi: 10.1097/TP.0000000000003977. Epub 2021 Oct 29.
Over the last 40 y, a specialized herd of miniature swine has been intentionally bred to develop lines of animals homozygous for the swine major histocompatibility complex (MHC), which have facilitated transplantation studies across reproducible MHC and minor antigen mismatch barriers. These MHC-characterized miniature swine (Mc-MS) have been used for the study of novel surgical techniques, various approaches to tolerance induction of solid organ and vascularized composite allografts, as well as studies of the immunobiology of allografts and xenografts. Mc-MS possess characteristics that are highly advantageous to these studies, and their continued use will likely continue to play an important role in bridging "bench-to-cage-to bedside" therapies in the field of transplantation. In this review, we highlight the seminal contributions of the Mc-MS model to the field and analyze their role in the broader context of large animal models in transplantation research.
在过去40年里，人们特意培育了一群特殊的小型猪，以培育出猪主要组织相容性复合体（MHC）纯合的动物品系，这有助于跨越可重复的MHC和次要抗原错配障碍进行移植研究。这些具有MHC特征的小型猪（Mc-MS）已被用于研究新型手术技术、诱导实体器官和血管化复合异体移植耐受的各种方法，以及异体移植和异种移植的免疫生物学研究。Mc-MS具有对这些研究极为有利的特征，它们的持续使用可能会在移植领域“从实验台到动物笼再到临床床边”的治疗衔接中继续发挥重要作用。在本综述中，我们强调了Mc-MS模型对该领域的开创性贡献，并分析了它们在移植研究中大型动物模型更广泛背景下的作用。
