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无症状嗜酸性粒细胞浸润,内镜及组织学检查结果符合嗜酸性胃炎

Asymptomatic Eosinophilic Infiltration with Endoscopic and Histological Findings Consistent with Eosinophilic Gastritis.

作者信息

Yamamoto Kazuki, Okamoto Takeshi, Fukuda Katsuyuki

机构信息

Department of Gastroenterology, St. Luke's International Hospital, Tokyo, Japan.

出版信息

Case Rep Gastroenterol. 2021 Jul 19;15(2):652-656. doi: 10.1159/000516688. eCollection 2021 May-Aug.

DOI:10.1159/000516688
PMID:34720822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8458926/
Abstract

Eosinophilic gastritis often presents with gastrointestinal symptoms in the absence of abnormal endoscopic findings. On the other hand, endoscopic changes due to eosinophilic infiltration in an asymptomatic patient are rare. A 29-year-old woman with a history of asthma on steroid inhalers presented for an annual medical checkup. Esophagogastroduodenoscopy revealed diffuse white granular patches in the body of the stomach, suggestive of eosinophilic gastritis. Histology showed over 100 eosinophils per high-power field, also consistent with eosinophilic gastritis. As the absence of symptoms precluded the diagnosis of eosinophilic gastritis, the patient was diagnosed with asymptomatic eosinophilic infiltration of the stomach.

摘要

嗜酸性胃炎常在无内镜异常发现的情况下出现胃肠道症状。另一方面,无症状患者因嗜酸性浸润导致的内镜改变很少见。一名29岁有使用类固醇吸入剂治疗哮喘病史的女性前来进行年度体检。食管胃十二指肠镜检查发现胃体部有弥漫性白色颗粒状斑片,提示嗜酸性胃炎。组织学检查显示每高倍视野有超过100个嗜酸性粒细胞,也符合嗜酸性胃炎。由于无症状,该患者无法诊断为嗜酸性胃炎,而是被诊断为无症状性胃嗜酸性浸润。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea3a/8458926/4d520cfb2476/crg-0015-0652-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea3a/8458926/7d164141571e/crg-0015-0652-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea3a/8458926/4d520cfb2476/crg-0015-0652-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea3a/8458926/7d164141571e/crg-0015-0652-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea3a/8458926/4d520cfb2476/crg-0015-0652-g02.jpg

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本文引用的文献

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Endosc Int Open. 2020 Dec;8(12):E1817-E1825. doi: 10.1055/a-1268-7312. Epub 2020 Nov 17.
2
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Dig Dis Sci. 2020 Jul;65(7):2024-2035. doi: 10.1007/s10620-019-05961-4. Epub 2019 Nov 26.
3
Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy.
基线胃肠道嗜酸性粒细胞增多在 IgE 介导的花生过敏的口服免疫治疗患者中很常见。
Front Immunol. 2018 Nov 22;9:2624. doi: 10.3389/fimmu.2018.02624. eCollection 2018.
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Diagnosis, Natural History and Treatment of Eosinophilic Enteritis: a Review.嗜酸性粒细胞性肠炎的诊断、自然史及治疗:综述
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Lancet Gastroenterol Hepatol. 2018 Apr;3(4):271-280. doi: 10.1016/S2468-1253(18)30005-0. Epub 2018 Mar 7.
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