Zhang Shengjun, Wang Zhenghua, Xu Guoping
Department of Pediatric Surgery, People's Hospital of Rizhao, Rizhao 276826, Shandong Province, China.
Department of Surgery, Rizhao Maternal and Child Health Care Hospital, Rizhao 276800, Shandong Province, China.
Evid Based Complement Alternat Med. 2021 Oct 20;2021:4575503. doi: 10.1155/2021/4575503. eCollection 2021.
To explore the therapeutic effect of amoxicillin and clavulanate potassium combined with Bazhengsan on pediatric urinary tract infection (UTI).
The data of 120 UTI children treated in Wuhan Xinzhou District People's Hospital from February 2019 to February 2020 were retrospectively analyzed. They were equally split into experimental group (EG) and control group (CG) according to the order of admission. All children were treated with amoxicillin and clavulanate potassium for suspension (twice a day), and EG was additionally treated with one dose of Bazhengsan daily. Both groups were treated for 10 days. After treatment, the immune function indexes, inflammatory factor levels, and clinical efficacy were compared before and after treatment.
No remarkable differences in the general data such as blood routine and urine routine results were observed between the two groups before treatment ( > 0.05). After treatment, EG achieved obviously better immune function indexes ( < 0.001) and lower levels of inflammatory factors ( < 0.05) compared with CG. Besides, the treatment effective rate in EG (96.7%) was higher than that in CG ( < 0.05).
Amoxicillin and clavulanate potassium combined with Bazhengsan can improve the immune function of UTI children and reduce the levels of inflammatory factors, with remarkable effects, which should be popularized in practice.
探讨阿莫西林克拉维酸钾联合八正散治疗小儿泌尿系统感染（UTI）的疗效。
回顾性分析2019年2月至2020年2月在武汉新洲区人民医院治疗的120例UTI患儿的数据。根据入院顺序将他们平均分为实验组（EG）和对照组（CG）。所有患儿均接受阿莫西林克拉维酸钾干混悬剂治疗（每日两次），实验组额外每日加服一剂八正散。两组均治疗10天。治疗后，比较两组治疗前后的免疫功能指标、炎症因子水平及临床疗效。
治疗前，两组血常规、尿常规等一般数据无显著差异（>0.05）。治疗后，与对照组相比，实验组免疫功能指标明显更好（<0.001），炎症因子水平更低（<0.05）。此外，实验组的治疗有效率（96.7%）高于对照组（<0.05）。
阿莫西林克拉维酸钾联合八正散可提高UTI患儿的免疫功能，降低炎症因子水平，疗效显著，值得在临床上推广应用。
