Muntean Carmen, Săsăran Maria
Department of Paediatrics I, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540142 Târgu Mureș, Romania.
Department of Paediatrics III, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540142 Târgu Mureș, Romania.
Children (Basel). 2021 May 20;8(5):419. doi: 10.3390/children8050419.
Vitamin D has emerged as a key factor in innate immunity. Its involvement in the pathogenesis of urinary tract infections (UTIs) has gained a lot of attention recently. The objective of this study is to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and first-time or recurrent UTIs in children. A prospective, case-control study was conducted on 101 pediatric patients, who were divided into two groups: 59 patients with UTIs and 42 age-matched healthy controls. Serum 25(OH)D was determined in each child and expressed in ng/mL. Vitamin D presented significantly lower values in study group subjects than in healthy controls ( < 0.01). Moreover, a significantly higher prevalence of vitamin D insufficiency and deficiency was found in children with UTIs ( < 0.01). Patients with recurrent UTIs presented significantly lower levels of vitamin D than those with first-time UTIs ( = 0.04). Urinary tract abnormalities did not seem to exercise an additional effect upon vitamin D levels within the study group. In conclusion, first-time and recurrent UTIs are associated with lower vitamin D levels. Further studies are necessary to validate our findings, as well as future longitudinal research regarding efficacy of vitamin D supplementation in children with UTIs.
维生素D已成为先天免疫的关键因素。其在尿路感染（UTIs）发病机制中的作用最近受到了广泛关注。本研究的目的是调查儿童血清25-羟基维生素D（25(OH)D）水平与首次或复发性UTIs之间的关联。对101名儿科患者进行了一项前瞻性病例对照研究，这些患者被分为两组：59名UTIs患者和42名年龄匹配的健康对照。测定了每个儿童的血清25(OH)D，并以ng/mL表示。研究组受试者的维生素D值显著低于健康对照组（<0.01）。此外，UTIs患儿中维生素D不足和缺乏的患病率显著更高（<0.01）。复发性UTIs患者的维生素D水平显著低于首次UTIs患者（=0.04）。尿路异常似乎对研究组内的维生素D水平没有额外影响。总之，首次和复发性UTIs与较低的维生素D水平相关。有必要进行进一步研究以验证我们的发现，以及未来关于补充维生素D对UTIs患儿疗效的纵向研究。
