血浆中耐碳青霉烯类肺炎克雷伯菌感染的代谢组学研究。
The Metabolome of Carbapenem-Resistant Klebsiella pneumoniae Infection in Plasma.
机构信息
Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Guangxi Medical University, No. 156 Heping Road, Liuzhou 545005, Guangxi Province, China.
出版信息
Dis Markers. 2021 Oct 22;2021:7155772. doi: 10.1155/2021/7155772. eCollection 2021.
AIM
Carbapenem-resistant - (CR-Kp-) mediated infections represent a challenge for clinical practitioners due to their expanding prevalence in hospital environments and antibiotic resistance. However, few studies have shown metabolic changes of carbapenem-resistant and CR-Kp-negative patients, and relevant studies are urgently needed.
METHODS
In this study, we comprehensively profile the metabolites of 20 CR-Kp-positive and 18 CR-Kp-negative patients in plasma by using 2D gas chromatography-time-of-flight mass spectrometry (GC×GC-TOFMS).
RESULTS
We identified 58 metabolites that were carbapenem-resistant -associated. N-Acetyl glucosamine, butanedioic acid, and myoinositol play a significant character in CR-Kp infection.
CONCLUSIONS
Our study provides valuable data to serve as potential targets for developing therapies against CR-Kp infection.
目的
由于碳青霉烯类耐药-（CR-Kp-）介导的感染在医院环境中的流行率不断上升以及抗生素耐药性的问题，给临床医生带来了挑战。然而，很少有研究表明碳青霉烯类耐药患者和 CR-Kp 阴性患者的代谢变化，因此迫切需要开展相关研究。
方法
在这项研究中，我们通过二维气相色谱-飞行时间质谱（GC×GC-TOFMS）对 20 名 CR-Kp 阳性患者和 18 名 CR-Kp 阴性患者的血浆进行了全面的代谢物分析。
结果
我们确定了 58 种与碳青霉烯类耐药相关的代谢物。N-乙酰葡萄糖胺、丁二酸和肌醇在 CR-Kp 感染中具有重要特征。
结论
我们的研究为开发针对 CR-Kp 感染的治疗方法提供了有价值的数据，这些数据可以作为潜在的治疗靶点。
Zotero 插件