利用甘油作为碳源的肺炎克雷伯氏菌作为微生物细胞工厂的潜力和局限性。
Potential and limitations of Klebsiella pneumoniae as a microbial cell factory utilizing glycerol as the carbon source.
机构信息
Bioenergy and Resource Management Centre, School of Water, Energy and Environment, Cranfield University, Cranfield MK43 0AL, United Kingdom.
School of Energy and Chemical Engineering, UNIST, 50 UNIST-gil, Ulsan 44919, Republic of Korea.
出版信息
Biotechnol Adv. 2018 Jan-Feb;36(1):150-167. doi: 10.1016/j.biotechadv.2017.10.004. Epub 2017 Oct 19.
Klebsiella pneumoniae is a Gram-negative facultative anaerobe that metabolizes glycerol efficiently under both aerobic and anaerobic conditions. This microbe is considered an outstanding biocatalyst for transforming glycerol into a variety of value-added products. Crude glycerol is a cheap carbon source and can be converted by K. pneumoniae into useful compounds such as lactic acid, 3-hydroxypropionic acid, ethanol, 1,3-propanediol, 2,3-butanediol, and succinic acid. This review summarizes glycerol metabolism in K. pneumoniae and its potential as a microbial cell factory for the production of commercially important acids and alcohols. Although many challenges remain, K. pneumoniae is a promising workhorse when glycerol is used as the carbon source.
肺炎克雷伯氏菌是一种革兰氏阴性兼性厌氧菌，能够在有氧和无氧条件下高效代谢甘油。这种微生物被认为是将甘油转化为各种高附加值产品的优秀生物催化剂。粗甘油是一种廉价的碳源，可以被肺炎克雷伯氏菌转化为有用的化合物，如乳酸、3-羟基丙酸、乙醇、1,3-丙二醇、2,3-丁二醇和琥珀酸。本文综述了肺炎克雷伯氏菌中的甘油代谢及其作为微生物细胞工厂生产商业上重要的酸和醇的潜力。尽管仍然存在许多挑战，但当甘油作为碳源时，肺炎克雷伯氏菌是一种很有前途的工程菌。
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