Ren Li, Chen Qibin, Min Su, Peng Fangliang, Wang Bin, Yu Jian, Zhang Yuxi
Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, China.
Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Transl Neurosci. 2021 Oct 25;12(1):396-406. doi: 10.1515/tnsci-2020-0193. eCollection 2021 Jan 1.
Postpartum depression (PPD) is a frequent mental disorder after delivery. In China, most parturients give birth with the assistance of labor analgesia (LA) or by cesarean section (CS); however, it is still unclear whether these two approaches reveal different effects on PPD.
One hundred and ninety-eight patients with single pregnancy at full term were allocated to receive either group LA or group CS. Maternal and neonatal variables in the perinatal period were recorded. Multivariate logistical regression analysis was conducted to evaluate the associated factors of PPD.
The incidence of PPD in group LA was lower than in group CS. Besides, eight factors were found to be potential predictors of PPD. Multivariate logistic model showed that LA was a protective factor against PPD. However, high family income and Edinburgh postnatal depression scale (EPDS) scores at 3 days postpartum were associated with an increased risk of PPD.
LA could reduce the incidence of PPD in women with single pregnancy at full term. Family income and EPDS scores in the early postpartum period were also related with PPD. Large sample size studies are needed to verify the impact of LA on the psychological states of postpartum women.
产后抑郁症（PPD）是分娩后常见的精神障碍。在中国，大多数产妇在分娩镇痛（LA）或剖宫产（CS）的辅助下分娩；然而，这两种分娩方式对产后抑郁症是否有不同影响仍不清楚。
198例单胎足月妊娠患者被分配接受分娩镇痛组或剖宫产组。记录围产期的母婴变量。进行多因素逻辑回归分析以评估产后抑郁症的相关因素。
分娩镇痛组产后抑郁症的发生率低于剖宫产组。此外，发现8个因素是产后抑郁症的潜在预测因素。多因素逻辑模型显示，分娩镇痛是预防产后抑郁症的保护因素。然而，高家庭收入和产后3天的爱丁堡产后抑郁量表（EPDS）评分与产后抑郁症风险增加有关。
分娩镇痛可降低单胎足月妊娠妇女产后抑郁症的发生率。家庭收入和产后早期的爱丁堡产后抑郁量表评分也与产后抑郁症有关。需要大样本研究来验证分娩镇痛对产后妇女心理状态的影响。
