Durrani Lubna, Ejaz Saman, Tavares Lorena B, Mohyeldin Moiud, Abureesh Deya, Boorenie Mustafa, Khan Safeera
Obstetrics and Gynecology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Bioethics, Columbia University, New York, USA.
Cureus. 2021 Oct 23;13(10):e18990. doi: 10.7759/cureus.18990. eCollection 2021 Oct.
Gestational diabetes mellitus (GDM) is a growing pregnancy-related health problem all over the world. It has been noticed that women with high serum ferritin levels have a strong relationship with GDM by increased insulin resistance and increased insulin secretion from the pancreas resulting in pancreatic beta-cell exhaustion. Heme iron is also responsible for increasing the body's iron store and hence causing oxidative injury to pancreatic cells. In this systematic review, we researched the association between high serum ferritin levels and GDM. Three databases were consulted for articles related to GDM and high ferritin. These include Medical Literature Analysis and Retrieval System Online (MEDLINE), PubMed, and PubMed Central (PMC). Additional articles were retrieved from the institutional database. After filtering, 10 articles were finally selected, and quality was checked using the Joanna Briggs Institute (JBI) Critical Appraisal quality check tool. Serum iron biomarkers including ferritin, iron, and soluble transferrin receptor (sTfR) were measured. Our systematic review indicates that high maternal serum ferritin has a significant role in the development of GDM. We have also noticed the importance of sTfR and serum hepcidin as biomarkers to monitor high ferritin levels. Our study also observed a positive relationship between high heme iron intake and gestational diabetes mellitus. Therefore, more research is required to understand this relationship to identify populations at risk.
妊娠期糖尿病（GDM）是全球范围内日益严重的与妊娠相关的健康问题。人们已经注意到，血清铁蛋白水平高的女性与GDM关系密切，这是由于胰岛素抵抗增加以及胰腺胰岛素分泌增加导致胰腺β细胞耗竭所致。血红素铁也会导致体内铁储存增加，从而对胰腺细胞造成氧化损伤。在本系统评价中，我们研究了高血清铁蛋白水平与GDM之间的关联。我们查阅了三个数据库以获取与GDM和高铁蛋白相关的文章。这些数据库包括医学文献分析和联机检索系统（MEDLINE）、PubMed和PubMed Central（PMC）。另外还从机构数据库中检索了一些文章。经过筛选，最终选定了10篇文章，并使用乔安娜·布里格斯研究所（JBI）的批判性评价质量检查工具对质量进行了检查。测量了包括铁蛋白、铁和可溶性转铁蛋白受体（sTfR）在内的血清铁生物标志物。我们的系统评价表明，孕妇血清铁蛋白水平高在GDM的发生发展中具有重要作用。我们还注意到sTfR和血清铁调素作为监测高铁蛋白水平生物标志物的重要性。我们的研究还观察到高血红素铁摄入量与妊娠期糖尿病之间存在正相关关系。因此，需要进行更多研究以了解这种关系，从而确定高危人群。
