Department of Endocrinology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu, China.
Front Endocrinol (Lausanne). 2024 Sep 16;15:1374253. doi: 10.3389/fendo.2024.1374253. eCollection 2024.
To explore the diagnostic value of glycated CD59 (gCD59) in gestational diabetes mellitus (GDM).
A total of 707 pregnant women who underwent the first visit in the obstetric outpatient clinic of the Affliated Suqian Hospital of Xuzhou Medical University from January 2022 to July 2023 were included, and were grouped according to the International Association of the Diabetes and Pregnancy Study Groups(IADPSG) diagnostic criteria, and finally 113 cases in the GDM group and 559 cases in the normal glucose tolerance (NGT) group were included, and the concentration of gCD59 was determined by enzyme-linked immunosorbent assay (ELISA). The baseline data characteristics of the two groups were compared, the risk factors for GDM were explored by multivariate binary logistic analysis, and the diagnostic value of gCD59 in predicting GDM was explored by receiver operating characteristic (ROC) curve analysis.
The level of gCD59 in the GDM group was significantly higher than that in the NGT group (1.49 SPU vs 0.87 SPU). Multivariate regression analysis showed that gCD59, diastolic blood pressure (DBP) and thyroid stimulating hormone (TSH) were independent risk factors for GDM.The area under the curve (AUC) of gCD59 for the diagnosis of GDM was 0.681 (95% : 0.583-0.717), with a sensitivity of 71.7% and a specificity of 58.3%. In combination with fasting glucose, gCD59 effectively diagnosed GDM with higher AUC of 0.871 (95% : 0.708-1.000).
gCD59 is an independent risk factor for GDM and a good biomarker for the diagnosis of GDM.
探讨糖化 CD59（gCD59）在妊娠期糖尿病（GDM）中的诊断价值。
选取 2022 年 1 月至 2023 年 7 月在徐州医科大学附属宿迁医院妇产科门诊首次就诊的 707 例孕妇，根据国际妊娠合并糖尿病研究组织（IADPSG）诊断标准进行分组，最终纳入 GDM 组 113 例和正常糖耐量（NGT）组 559 例，采用酶联免疫吸附试验（ELISA）测定 gCD59 浓度。比较两组的基线资料特征，采用多因素二分类 Logistic 回归分析 GDM 的危险因素，采用受试者工作特征（ROC）曲线分析 gCD59 预测 GDM 的诊断价值。
GDM 组 gCD59 水平显著高于 NGT 组（1.49 SPU 比 0.87 SPU）。多因素回归分析显示，gCD59、舒张压（DBP）和促甲状腺激素（TSH）是 GDM 的独立危险因素。gCD59 诊断 GDM 的曲线下面积（AUC）为 0.681（95%：0.583-0.717），灵敏度为 71.7%，特异度为 58.3%。与空腹血糖联合检测时，gCD59 诊断 GDM 的 AUC 有效提高至 0.871（95%：0.708-1.000）。
gCD59 是 GDM 的独立危险因素，也是诊断 GDM 的良好生物标志物。
