Nakamura Atsushi, Yoshimura Tsubasa, Ichikawa Takeshi
Hepatology, Nippon Koukan Hospital, Kawasaki, JPN.
Gastroenterology, Nippon Koukan Hospital, Kawasaki, JPN.
Cureus. 2021 Oct 24;13(10):e19001. doi: 10.7759/cureus.19001. eCollection 2021 Oct.
Sofosbuvir/velpatasvir therapy can safely treat hepatitis C virus (HCV)-related decompensated cirrhosis and has been shown to improve liver function at an early stage. However, the pathophysiology of the liver during treatment remains unclear. In this case report, we analyzed hepatic morphology on magnetic resonance imaging during the treatment period and confirmed that liver function and malnutrition were greatly improved with the elimination of HCV, and that rapid hemodynamic changes were occurring in the liver.
索磷布韦/维帕他韦疗法可安全治疗丙型肝炎病毒(HCV)相关失代偿性肝硬化,且已证明在早期可改善肝功能。然而,治疗期间肝脏的病理生理学仍不清楚。在本病例报告中,我们分析了治疗期间磁共振成像的肝脏形态,证实随着HCV的清除,肝功能和营养不良状况得到极大改善,且肝脏正在发生快速的血流动力学变化。