激素性股骨头坏死的危险因素及发病机制——一项范围综述
Risk factors and pathogenesis of steroid-induced osteonecrosis of femoral head - A scoping review.
作者信息
Birla Vikas, Vaish Abhishek, Vaishya Raju
机构信息
Department of Orthopaedics and Joint Replacement Surgery, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi, 110076, India.
出版信息
J Clin Orthop Trauma. 2021 Oct 13;23:101643. doi: 10.1016/j.jcot.2021.101643. eCollection 2021 Dec.
Abstract
Steroid induced osteonecrosis of the femoral head is commonly seen in clinical practice, but yet not fully understood. It is intriguing why only some cases develop and others escape from it. We did an extensive and up to date literature review on it, with the aim to identify its incidence, associated risk factor and pathogenesis. We found that the incidence ranged from 03 to 40%, and was more with associated risk factors. Several risk factors were identified, which included higher dose and prolonged duration of steroid consumption, and underlying disease for which the steroids were given. Pathogenesis of this disease is complex and not yet fully understood. Awareness about this condition and associated risk factors should help the clinicians in identifying the cases who are prone to develop osteonecrosis with the use of steroids.
摘要
类固醇诱导的股骨头坏死在临床实践中很常见，但尚未被完全理解。令人好奇的是，为什么只有一些病例会发生，而其他病例则不会。我们对其进行了广泛且最新的文献综述，目的是确定其发病率、相关危险因素和发病机制。我们发现发病率在0.3%至40%之间，且伴有相关危险因素时发病率更高。确定了几个危险因素，包括更高剂量和更长时间的类固醇使用，以及使用类固醇所针对的基础疾病。这种疾病的发病机制很复杂，尚未被完全理解。对这种情况和相关危险因素的认识应有助于临床医生识别使用类固醇时易发生骨坏死的病例。
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