Lee Dong-Joon, Kim Hyun-Yi, Lee Seung-Jun, Jung Han-Sung
Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea.
NGeneS Inc., Ansan-si, South Korea.
Front Cell Dev Biol. 2021 Oct 14;9:723326. doi: 10.3389/fcell.2021.723326. eCollection 2021.
Over the past 40 years, studies on tooth regeneration have been conducted. These studies comprised two main flows: some focused on epithelial-mesenchymal interaction in the odontogenic region, whereas others focused on creating a supernumerary tooth in the non-odontogenic region. Recently, the scope of the research has moved from conventional gene modification and molecular therapy to genome and transcriptome sequencing analyses. However, these sequencing data have been produced only in the odontogenic region. We provide RNA-Seq data of not only the odontogenic region but also the non-odontogenic region, which loses tooth-forming capacity during development and remains a rudiment. Sequencing data were collected from mouse embryos at three different stages of tooth development. These data will expand our understanding of tooth development and will help in designing developmental and regenerative studies from a new perspective.
在过去40年里，人们开展了关于牙齿再生的研究。这些研究主要有两个方向：一些聚焦于牙源性区域的上皮-间充质相互作用，而另一些则致力于在非牙源性区域制造多生牙。最近，研究范围已从传统的基因修饰和分子疗法转向基因组和转录组测序分析。然而，这些测序数据仅在牙源性区域产生。我们提供了不仅来自牙源性区域，还来自非牙源性区域的RNA测序数据，该区域在发育过程中失去了牙齿形成能力，仅保留一个残迹。测序数据是从小鼠胚胎牙齿发育的三个不同阶段收集的。这些数据将拓宽我们对牙齿发育的理解，并有助于从新的角度设计发育和再生研究。
