AGO蛋白ALG-1和ALG-2与抗逆性和蛋白质稳态相关。
The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis.
作者信息
Finger Fabian, Ottens Franziska, Hoppe Thorsten
机构信息
Institute for Genetics, University of Cologne, 50674 Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.
出版信息
MicroPubl Biol. 2021 Oct 14;2021. doi: 10.17912/micropub.biology.000457. eCollection 2021.
The conserved Argonaute-family members ALG-1 and ALG-2 are known to regulate processing and maturation of microRNAs to target mRNAs for degradation or translational inhibition (Bouasker and Simard 2012; Meister 2013). Consequently, depletion of and results in multiple phenotypes. Our data describe a role of microRNA-regulation in stress resistance and proteostasis with special emphasis on ubiquitin-dependent degradation pathways, such as ubiquitin fusion degradation (UFD) and endoplasmic reticulum (ER)-associated protein degradation (ERAD).
已知保守的AGO蛋白家族成员ALG-1和ALG-2可调节微小RNA的加工和成熟，以靶向信使核糖核酸进行降解或翻译抑制（Bouasker和Simard，2012年；Meister，2013年）。因此，ALG-1和ALG-2的缺失会导致多种表型。我们的数据描述了微小RNA调节在抗逆性和蛋白质稳态中的作用，特别强调了泛素依赖性降解途径，如泛素融合降解（UFD）和内质网（ER）相关蛋白降解（ERAD）。
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